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FLASH GENE
Symbol E2F2 contributors: mct - updated : 24-10-2014
HGNC name E2F transcription factor 2
HGNC id 3114
Location 1p36.11      Physical location : 23.832.921 - 23.857.713
Synonym symbol(s) E2F-2
DNA
TYPE functioning gene
STRUCTURE 21.00 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunelymph node   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative leucine zippers
  • a carboxyterminal domain of interaction with pRB
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in cell proliferation
  • controlling genes regulating S phase entry and DNA synthesis
  • could exert a strong influence over the susceptibility to oncogenic transformation
  • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • retinoblastoma RB1 binding
  • interaction with p107 (RBL1), p130 (RBL2) binding
  • ALYREF is a transcriptional co-activator, associating with DNA-bound E2F2 and represses its transcriptional activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS