SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| text
| localize to the nucleus and cytoplasm of primordial germ cells |
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localize to the basal bodies of primary cilia and, together, are required for primary cilia formation  |
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localizes to the primary cilium and is required for its proper formation |
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predominantly located in granules in the cytoplasm |
| basic FUNCTION
| Iguana proteins (DZIP1 and DZIP1L) localize to the basal bodies of primary cilia and, together, are required for primary cilia formation |
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critical and broadly conserved function for Iguana is in ciliogenesis and that this function has come to be required for Hedgehog signaling in vertebrates |
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is required for ciliogenesis |
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is the first known ciliogenic protein that regulates Hedgehog signaling through a dual mechanism and that biochemically links intraflagellar transport (IFT) machinery with Hedgehog pathway components |
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has bipartite positive and negative functions in the Hh pathway |
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appears to be important for the formation of stress granules during the stress response |
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DZIP1 is involved in the Hedgehog signaling pathway |
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is likely a component of different ribonucleoproteins associated with translating polysomes and with RNA granules |
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unique cascade consisting of GSK3B, DZIP1, and RAB8A that regulates ciliogenesis after mitosis |
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centrosome protein DZIP1 mediates the assembly of the BBSome-DZIP1-PCM1 complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome |
