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FLASH GENE
Symbol DYRK4 contributors: mct - updated : 19-10-2011
HGNC name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
HGNC id 3095
Location 12p13.3      Physical location : 4.699.243 - 4.723.040
Synonym name dual specificity tyrosine-phosphorylation-regulated kinase 4
EC.number 2.7.12.1
DNA
TYPE functioning gene
STRUCTURE 23.80 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map see FGF6
RNA
TRANSCRIPTS type messenger
text alternative splicing event that involved the inclusion of an extra exon (exon 6) (PMID: 21127067)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1860 - 520 - 2011 21127067
  • long isoform was only partially segregated in the nucleus suggesting that full nuclear accumulation was prevented by mechanisms such as strong CRM1-independent nuclear export, NLS masking, or an interaction with cytosolic proteins
    • - - 1676 - 632 - 2011 21127067
    EXPRESSION
    Rna function DYRK4 mRNA is detected in human cell lines not derived from testis, such as A549 or HEK-293
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative bipartite NLS within the extended N-terminal region
  • protein kinase domain
    • HOMOLOGY
    interspecies homolog to Drosophila minibrain
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • MNB/DYRK subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • preferential cytoplasmic localization
    • basic FUNCTION
  • putatively involved in cell growth and development and in neuronal differentiation
  • testis-specific kinase with a very restricted expression to stage VIII postmeiotic spermatids, but dispensable for male fertility
  • autophosphorylated on tyrosine residues and the phosphorylation of the second tyrosine in the YXY motif is necessary for its kinase activity
  • can phosphorylate target sequences not recognized by DYRK1A or DYRK2
  • DYRK1A, DYRK2, and DYRK4 phosphorylate distinct although overlapping sets of the 720 different peptides in the phosphosite array
  • DYRK1A, DYRK3, DYRK4 implicated in the regulation of cytoskeletal organization and process outgrowth in neurons
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DCX is likely one relevant DYRK1A, DYRK3, DYRK4 target
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Dyrk4-deficient mice are fertile