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FLASH GENE
Symbol DYRK3 contributors: mct/npt/pgu - updated : 14-04-2015
HGNC name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
HGNC id 3094
Location 1q32.1      Physical location : 206.808.880 - 206.822.541
Synonym name
  • regulatory erythroid kinase
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5
  • protein kinase Dyrk3
  • Synonym symbol(s) RED, REDK, DYRK5, hYAK3-2
    EC.number 2.7.12.1
    DNA
    TYPE functioning gene
    STRUCTURE 13.66 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure GATA-1 binding site
    MAPPING cloned Y linked N status provisional
    Physical map
    SLC26A9 1q31-q32 solute carrier family 26, member 9 LOC391156 1 LOC391156 FNBP2 1q31.3 formin binding protein 2 IKBKE 1q32.1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon RASSF5 1q32.1 Ras association (RalGDS/AF-6) domain family 5 LGTN 1q31-q32 ligatin DYRK3 1q32 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 MAPKAPK2 1q32 mitogen-activated protein kinase-activated protein kinase 2 IL10 1q31.3-q32.1 interleukin 10 IL19 1q32.2 interleukin 19 IL20 1q32 interleukin 20 IL24 1q32 interleukin 24 TOSO 1q32.1 regulator of Fas-induced apoptosis PIGR 1q32 polymeric immunoglobulin receptor FKSG87 1q32.1 FKSG87 protein LOC387623 1 hypothetical gene supported by NM_024115 SARG 1q32.1 specifically androgen-regulated protein DKFZp451J1719 1q32.1 hypothetical DKFZp451J1719 PFKFB2 1q31 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 C4BPB 1q32 complement component 4 binding protein, beta C4BPA 1q32 complement component 4 binding protein, alpha LOC343024 1q32.1 similar to C4BP alpha chain precursor - rabbit C4BPAL2 1q32 complement component 4 binding protein, alpha-like 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2301 - 568 - 2008 18854306
  • isoform b
  • RED-S
  • 3 - 2207 - 588 - 1998 9748265
  • isoform a
  • RED-L
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemtestis   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain of DYRK3 contains a predicted low complexity sequence, which may allow partitioning into stress granules and contribute to liquid-liquid unmixing
  • a canonical kinase domain between a large N terminal region
  • a short C terminal extension
  • HOMOLOGY
    interspecies homolog to murine Dyrk3 (89.9pc)
    homolog to rattus Dyrk3 (91.1pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MNB/DYRK subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine tyrosine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • also at least partially localized in the nucleus
  • DYRK3 localizes to Stress granules during oxidative and osmotic stress
  • basic FUNCTION
  • serine/threonine and tyrosine kinase, phosphorylating histone H2B, putatively involved in cell growth and development
  • might act to attenuate erythroblast development
  • attenuates (and possibly apportions) red cell production selectively during anemia
  • may act via intrinsic erythroid cell mechanisms to selectively place an upper limit on stress erythropoiesis
  • promotes cell survival through pphosphorylation and activation of SIRT1 with DYRK1A
  • regulates erythropoiesis through as yet unknown molecular pathways
  • DYRK1A, DYRK3, DYRK4 implicated in the regulation of cytoskeletal organization and process outgrowth in neurons
  • during cellular stress the dual specificity kinase DYRK3 regulates the stability of P-granule-like structures and MTOR signaling
  • displays a cyclic partitioning mechanism between stress granules and the cytosol via a low-complexity domain in its N terminus and its kinase activity
  • dynamically regulates its own partitioning between stress granules and the cytosol through its kinase activity, suggesting a cyclic partitioning mechanism that couples compartmentalization through liquid phase transition with cellular signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DCX is likely one relevant DYRK1A, DYRK3, DYRK4 target
  • when DYRK3 is active, it allows stress granule dissolution, releasing MTOR for signaling and promoting its activity by directly phosphorylating the MTOR inhibitor AKT1S1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS