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FLASH GENE
Symbol DYRK2 contributors: mct/npt/pgu - updated : 28-02-2015
HGNC name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
HGNC id 3093
Location 12q15      Physical location : 68.042.511 - 68.056.443
Synonym symbol(s) FLJ21365, FLJ21217
EC.number 2.7.12.1
DNA
TYPE functioning gene
STRUCTURE 13.93 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
IRAK3 12q13.13 interleukin-1 receptor-associated kinase 3 RBMS1P 12q14.2 RNA binding motif, single stranded interacting protein 1, pseudogene LOC387866 12 LOC387866 LOC390340 12 similar to IAP-associated factor VIAF1; phosducin-like 2 HELB 12q14.2 helicase (DNA) B GRIP1 12q14.1-q14.2 glutamate receptor interacting protein 1 HGT2 12q14.3 glutamate receptor interacting protein 1 TIP120A 12q14 glutamate receptor interacting protein 1 LOC390341 12 similar to nuclear localization signal containing protein deleted in Velo-Cardio-Facial syndrome DYRK2 12q14.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 LOC341333 12q14.3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) IFNG 12q14-q15 interferon, gamma IL26 12q15 interleukin 26 IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 6010 - 528 - 2007 17349958
3 initiation site 6159 - 601 - 2007 17349958
5' insertion
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 stomach    
Endocrinepancreas    
Lymphoid/Immunelymph node    
 thymus    
Nervousnerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • functional nuclear localization signal at N-terminal domain, domain that is critical for its nuclear targeting in the apoptotic response to DNA damage
  • HOMOLOGY
    interspecies homolog to Drosophila smi35a
    intraspecies homolog to DYRK3
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CMGC (cyclin-dependent kinases, mitogen-activated protein kinases, GSK and CDK-like kinases) family of protein kinases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text translocates from the cytoplasm to the nucleus in response to DNA damage
    basic FUNCTION
  • serine/threonine and tyrosine kinase, phosphorylating histone H2B
  • putatively involved in cell growth and development
  • could be novel and essential regulatory molecules for the regulation of cell fate including apoptosis
  • having an unexpected role as a scaffold for an E3 ubiquitin ligase complex, its kinase activity is required for the phosphorylation and subsequent degradation of the substrate, katanin p60
  • presumed to be involved in regulating key developmental and cellular processes such as neurogenesis, cell proliferation, cytokinesis, and cellular differentiation
  • has unexpected role as a scaffold for an E3 ubiquitin ligase complex
  • involved in the response to DNA damage through TP53 phosphorylation
  • DYRK1A, DYRK2, and DYRK4 phosphorylate distinct although overlapping sets of the 720 different peptides in the phosphosite array
  • zinc finger transcriptional repressor, and an important regulator of epithelial-mesenchymal transition (EMT)
  • is a novel negative regulator of cardiomyocyte growth
  • expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence
  • DYRK2 down-regulates key molecules on cell cycle control and has functions during cell division
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATM (essential role for ATM in the intracellular control of DYRK2)
  • stable complex of DYRK2 with MDM2 at the nucleus (nuclear and not cytoplasmic DYRK2 is ubiquitinated by MDM2, resulting in its constitutive degradation)
  • regulates tumor progression through modulation of JUN and MYC
  • is a SIAH2 interaction partner that phosphorylates SIAH2 at five residues (Ser16, Thr26, Ser28, Ser68, and Thr119)
  • during the cell cycle, DYRK2 interacts with TERT at the G2/M phase and induces degradation
  • DYRK2-associated DDB1-UBR5-VPRBP E3 ligase inhibits telomerase by TERT degradation
  • DYRK2 regulates cancer invasion and metastasis by degrading SNAI1
  • interaction of GSK3B and its priming kinase DYRK2 regulate the activity of EIF2B in cardiac myocytes
  • post-translational regulation of NR1I2 via phosphorylation-facilitated ubiquitination by DYRK2 and UBR5
  • cell & other
    REGULATION
    activated by ATM and induces apoptosis by phosphorylating TP53 at Ser46
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in esophageal and lung adenocarcinoma
    tumoral     --over  
    in gastric cancer
    tumoral     --low  
    was a strong predictor of disease progression in non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascular  
    could serve as a therapeutic option to regulate myocardial growth
    ANIMAL & CELL MODELS