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FLASH GENE

Symbol

DYNLT3

contributors: mct - updated : 12-07-2007

HGNC name	dynein, light chain, Tctex-type 3
HGNC id	11694

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xp21.1      Physical location : 37.698.089 - 37.706.889
Synonym name	dynein, X-linked 1, light chain
	t-complex-associated-testis-expressed 1-like
Synonym symbol(s)	TCTEX1L, TCTE1L, RP3

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	8.00 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Nervous brain forebrain cerebral cortex frontal highly   nerve       highly Reproductive male system testis       Skin/Tegument skin       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cells

System Cell Pubmed Species Stage Rna symbol   digestive

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	retina, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Tcte1l

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microtubule
text	localized to the Golgi apparatus in interphases fibroblast, redistributed onto mitotic spindles

basic FUNCTION	contributes to dynein cargo binding specificity
	may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole
	links cytoplasmic dynein to BUB3 containing spindle checkpoint complexes and contribute to checkpoint complex function during congression and/or during the inactivation of the checkpoint by transporting the complexes from kinetochores to spindle poles

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	DYNLT light chain family has two members, DYNLT1 (previously called Tctex1) and DYNLT3 (previously called rp3)
	DYNLT1-DYNLT3 heterodimer did not bind to the intermediate chain (intermediate chain binding limits the incorporation of DYNLT heterodimers into the dynein complex and demonstrates that only a subset of the possible combinations of subunit isoforms can be utilized during the assembly of the dynein cargo binding domain)

INTERACTION

DNA

RNA

small molecule

protein	interacting with PTHR1
	binds to BUB3, a spindle checkpoint protein (binds exclusively to DYNLT3 and not to the other dynein light chains), co-localizes with BUB3 at prometaphase kinetochores

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS