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FLASH GENE
Symbol DYNLT3 contributors: mct - updated : 12-07-2007
HGNC name dynein, light chain, Tctex-type 3
HGNC id 11694
Location Xp21.1      Physical location : 37.698.089 - 37.706.889
Synonym name
  • dynein, X-linked 1, light chain
  • t-complex-associated-testis-expressed 1-like
  • Synonym symbol(s) TCTEX1L, TCTE1L, RP3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 8.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousbrainforebraincerebral cortexfrontalhighly
     nerve   highly
    Reproductivemale systemtestis   
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text retina, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Tcte1l
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text localized to the Golgi apparatus in interphases fibroblast, redistributed onto mitotic spindles
    basic FUNCTION
  • contributes to dynein cargo binding specificity
  • may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole
  • links cytoplasmic dynein to BUB3 containing spindle checkpoint complexes and contribute to checkpoint complex function during congression and/or during the inactivation of the checkpoint by transporting the complexes from kinetochores to spindle poles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • DYNLT light chain family has two members, DYNLT1 (previously called Tctex1) and DYNLT3 (previously called rp3)
  • DYNLT1-DYNLT3 heterodimer did not bind to the intermediate chain (intermediate chain binding limits the incorporation of DYNLT heterodimers into the dynein complex and demonstrates that only a subset of the possible combinations of subunit isoforms can be utilized during the assembly of the dynein cargo binding domain)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTHR1
  • binds to BUB3, a spindle checkpoint protein (binds exclusively to DYNLT3 and not to the other dynein light chains), co-localizes with BUB3 at prometaphase kinetochores
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS