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FLASH GENE
Symbol DYNLRB1 contributors: - updated : 21-02-2006
HGNC name dynein, light chain, roadblock-type 1
HGNC id 15468
Location 20q12-q13.1      Physical location : 33.104.203 - 33.128.761
Synonym name
  • dynein, cytoplasmic, light polypeptide 2A
  • dynein-associated protein Km23
  • bithoraxoid-like protein
  • Synonym symbol(s) BLP, BITH, HSPC162, MGC15113, DNCL2A, DNCL2A, DNLC2A
    DNA
    TYPE functioning gene
    STRUCTURE 24.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located near marker D20S106
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 702 10.9 96 upregulated in hepatocellular carcinomas Jiang
    - splicing 781 - 63 - Jiang
    containing an alternate exon compared to variant 1 resulting in an isoform having a shorter N-terminus
    - splicing 1526 - 47 - Jiang
    having multiple differences in the coding sequence and 3' UTR compared to variant 1 which cause a frameshift
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon lowly
     intestinesmall intestine  lowly
     liver   highly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  lowly
     male systemtestis  lowly
    Respiratorylung   lowly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta (moderately)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Dncl2a
    intraspecies paralog to DNCL2B
    Homologene
    FAMILY
  • GAMAD family
  • MPP6 family
  • CATEGORY motor/contractile , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • involved in tumor progression
  • involved in microtubule-based movement
  • involved in assembly and motor function of dynein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component included in cytoplasmic dynein complex(dynein light chain)
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding with BMF and BCL2L11
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinomas (variant 1)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS