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FLASH GENE
Symbol DYNLL2 contributors: mct/npt - updated : 10-07-2008
HGNC name dynein, light chain, LC8-type 2
HGNC id 24596
Location 17q22      Physical location : 56.160.779 - 56.167.618
Synonym name dynein light chain 2, cytoplasmic
Synonym symbol(s) DNCL1B, Dlc2, MGC17810
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text alternatively spliced exon B required for binding of DYNLL2 to MYO5A
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 735 10.3 89 - Pfister (2005)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Reproductivefemale systembreastmammary gland highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • dynein light chain family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • dynein light-chain proteins, found as components of both dynein and myosin V motor complexes, connecting the complexes to their cargoes
  • function as an adaptor to link the myosin to certain cargo
  • DYNLL1, DYNLL2 are required for outer arm dynein motor function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with MYO5A (Hodi 2006)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS