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FLASH GENE
Symbol DYNC2LI1 contributors: mct - updated : 28-12-2020
HGNC name dynein, cytoplasmic 2, light intermediate chain 1
HGNC id 24595
Corresponding disease
SRTD15 short-rib thoracic dysplasia 15 with polydactyly
Location 2p21      Physical location : 44.001.177 - 44.037.147
Synonym name
  • dynein 2 light intermediate chain
  • hypothetical protein D2LIC
  • Synonym symbol(s) D2LIC, LIC3, CGI-60, DKFZp564A033
    DNA
    TYPE functioning gene
    STRUCTURE 54.31 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1404 39 351 - 2002 11907264
    13 exons encoding the isoform 1
    6 - 1157 22 201 - 2002 11907264
    six exons encoding the isoform 2
    - - 1418 37 334 - 2002 11907264
    twelve exons encoding the isoform 3
    14 - 2202 - 374 - 2002 11907264
    14 - 2199 - 373 - 2002 11907264
    13 - 1402 - 352 - 2002 11907264
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemtestis   
    Urinarybladder   highly
     kidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text higlhy in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Dync2li1
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION may play a role in maintaining Golgi organization by binding cytoplasmic dynein 2 to its Golgi-associated cargo
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subunit of the cytoplasmic dynein 2 complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DYNC2LI1 interacts with DYNC2H1 to form the dynein-2 complex important for retrograde intraflagellar transport (IFT)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRTD15
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS