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FLASH GENE
Symbol DYNC1LI1 contributors: npt/mct - updated : 04-11-2009
HGNC name dynein, cytoplasmic 1, light intermediate chain 1
HGNC id 18745
Location 3p22.2      Physical location : 32.567.464 - 32.612.366
Synonym name
  • dynein light chain-A
  • dynein, cytoplasmic, light intermediate polypeptide 1
  • dynein light intermediate chain 1, cytosolic
  • Synonym symbol(s) DNCLI1, FLJ10219, LIC1, DLC-A
    DNA
    TYPE functioning gene
    STRUCTURE 44.88 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2498 - 523 - Sivaram (2009)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Nervousbrain    
    Reproductivefemale systemuterus   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text placenta,stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • dynein light intermediate chain family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • retrograde motor protein, may be involved in small GTPase mediated signal transduction
  • its Cdk1 phosphorylated form is required to remove MAD1L1/MAD2L1 and ZW10 but not BUB1B from kinetochores during spindle assembly checkpoint silencing (Sivaram 2009)
  • functions more specifically in the selective removal of spindle assembly checkpoint components from kinetochores, but does not appear to participate in other mitotic dynein-associated functions (Sivaram 2009)
  • with DYNC1LI2, define distinct dynein complexes that function at the Golgi versus recycling endosomes, respectively, suggesting that functional populations of dynein mediate discrete intracellular trafficking pathways (Palmer 2009)
  • CELLULAR PROCESS cell cycle, division
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • cytoplasmic dynein made of two heavy and several light and intermediate chains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • small GTPase Rab4A heavy and intermediate chain
  • cell & other
  • microtubule binding
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS