basic FUNCTION
| retrograde motor protein, may be involved in small GTPase mediated signal transduction |
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its Cdk1 phosphorylated form is required to remove MAD1L1/MAD2L1 and ZW10 but not BUB1B from kinetochores during spindle assembly checkpoint silencing (Sivaram 2009) |
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functions more specifically in the selective removal of spindle assembly checkpoint components from kinetochores, but does not appear to participate in other mitotic dynein-associated functions (Sivaram 2009) |
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with DYNC1LI2, define distinct dynein complexes that function at the Golgi versus recycling endosomes, respectively, suggesting that functional populations of dynein mediate discrete intracellular trafficking pathways (Palmer 2009) |