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FLASH GENE
Symbol DYNC1I2 contributors: - updated : 06-03-2006
HGNC name dynein, cytoplasmic, intermediate polypeptide 2
HGNC id 2964
Location 2q31.1      Physical location : 172.543.981 - 172.604.919
Synonym symbol(s) DNCI2, IC2
DNA
TYPE functioning gene
STRUCTURE 60.00 kb     18 Exon(s)
MAPPING cloned Y linked   status tentative : very preliminary evidence
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
five (? or seven) WD repeats
HOMOLOGY
interspecies homolog to murine Dncic1
Homologene
FAMILY dynein intermediate chain family
CATEGORY motor/contractile
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
basic FUNCTION
  • involved in intracellular movement or organelles and vesicles or in the orientation of the mitotic spindle apparatus
  • directing the dynein molecule to its appropriate subcellular target sites
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • cytoplasmic dynein made of two heavy and several light and intermediate chains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein heavy and light chains
    cell & other microtubule binding
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS