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FLASH GENE
Symbol DVL2 contributors: mct - updated : 01-04-2014
HGNC name dishevelled, dsh homolog 2 (Drosophila)
HGNC id 3086
Location 17p13.2      Physical location : 7.128.660 - 7.137.863
Synonym name dishevelled 2 (homologous to Drosophila dsh)
DNA
TYPE functioning gene
STRUCTURE 9.20 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3046 - 736 - 1999 10330181
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal DSH/DIX motif
  • Dlg, Discs-large suppressor tumor protein (DHR/GLGZ/PDZ) motif
  • a PDZ (dhr) domain
  • conjugated PhosphoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila dishevelled segment polarity gene 2
    ortholog to murine Dvl2
    homolog to C.elegans t05c12.6a
    intraspecies paralog to DVL1, DVL3
    Homologene
    FAMILY DSH family
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text localized to the spindles and spindle poles during mitosis
    basic FUNCTION
  • activated in WNT signal transduction
  • may play a role in the signal transduction pathway mediated by multiple WNT genes
  • DVL2 and beta-catenin are crucially important substrates for tyrosine phosphorylation in the canonical Wnt/beta-catenin pathway
  • DVL1, DVL2, DVL3 are core components in the correct routing and transmission of canonical and non-canonical Wnt signals, most likely by acting in large multiprotein complexes
  • involved in the activation of a spindle assembly checkpoint (SAC) kinase, RPS27, and the recruitment of other SAC components, BUB1 and BUBR1, to the kinetochores
  • involved in mitotic progression by regulating the dynamics of MT plus-ends and the SAC in PLK1-dependent and -independent manners
  • may be required for spindle orientation but not for bipolar spindle formation
  • regulator for faithful mitotic progression
  • DVL2 has potentially an inhibitory role in myogenesis and STAU1 coordinates myogenesis through the regulation of DVL2 mRNA
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • links at least one Frizzled family member (FZD4) to clathrin-mediated endocytosis
  • SRC binds DVL2, a key phosphoprotein in Wnt signaling, at two positions: an SH3-binding domain and a C-terminal domain
  • GABARAPL1 is a tumor repressor inhibiting WNT signaling via mediating DVL2 degradation through the autophagy pathway
  • STAU1 binds to 3prime untranslated region (UTR) of DVL2 mRNA, and after induction of myogenic differentiation, this association was decreased
  • DACT3 promoted DVL2 degradation
  • DVL2 no longer bound to NXN is now positioned to prime the Wnt pathway(s) required for primitive endoderm (PrE) formation
  • IRS1/2 promotes EMT and cell proliferation through stabilizing DVL2
  • role of APPL1 as a positive regulator of DVL2-dependent transcriptional activity of JUN
  • cell & other
    REGULATION
    Other phosphorylated at Thr206 by a mitotic kinase, PLK1, and this phosphorylation was required for spindle orientation and stable microtubule (MT)-KT attachment
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    in postdevelopmental cells results in aberrant cell membrane activity and actin disorganization
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS