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FLASH GENE
Symbol DVL1 contributors: mct/pgu - updated : 16-04-2015
HGNC name dishevelled, dsh homolog 1 (Drosophila)
HGNC id 3084
Corresponding disease
DEL1P36 chromosome 1p subtelomeric deletion syndrome
RBNSOS Robinow Syndrome, osteosclerotic
Location 1p36.33      Physical location : 1.270.658 - 1.284.492
Synonym name
  • dishevelled 1 (homologous to Drosophila dsh)
  • segment polarity protein dishevelled homolog DVL-1
  • DSH homolog 1
  • dishevelled-1
  • DSH homolog 1-like
  • segment polarity protein dishevelled homolog DVL-1-like
  • Synonym symbol(s) DVL, DVL1L1, MGC54245, DVL1P1
    DNA
    TYPE functioning gene
    STRUCTURE 13.84 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ22639 1p36.33 hypothetical protein FLJ22639 LOC284591 1p36.33 hypothetical protein LOC284591 LOC388773 1 similar to chromosome 14 open reading frame 24 LOC388579 1 similar to beta-tubulin 4Q LOC388580 1 hypothetical gene supported by AF148950 FLJ20584 1p36.33 hypothetical protein FLJ20584 LOC390987 1 similar to F12M16.16 FLJ36119 1p36.33 hypothetical protein FLJ36119 TNFRSF18 1p36.3 tumor necrosis factor receptor superfamily, member 18 TNFRSF4 1p36 tumor necrosis factor receptor superfamily, member 4 Cab45 1p36.33 calcium binding protein Cab45 precursor B3GALT6 1p36.33 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 LOC388581 1 similar to RIKEN cDNA 1110035L05 UBE2J2 1p36.33 ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) SCNN1D 1p36.33 sodium channel, nonvoltage-gated 1, delta CENTB5 1p36 centaurin, beta 5 FLJ90811 1p36.33 hypothetical protein FLJ90811 LOC388774 1 similar to hypothetical protein FLJ20542 1p36.33 hypothetical protein FLJ20542 TAS1R3 1p36.33 taste receptor, type 1, member 3 DVL1 1p36.33 dishevelled, dsh homolog 1 (Drosophila) MGC3047 1p36.33 hypothetical protein MGC3047 AKIP 1p36.33 aurora-A kinase interacting protein LOC388775 1 similar to testis-specific protein NYD-TSP1 MRPL20 1p36.3-36.2 mitochondrial ribosomal protein L20 LOC391207 1 LOC391207 LOC388582 1 LOC388582 WARP 1p36.33 von Willebrand factor A domain-related protein FLJ37183 1p36.33 FLJ37183 protein TOB3 1p36.33 FLJ37183 protein FLJ10709 1p36.33 hypothetical protein FLJ10709 TLR5 1q33.3 toll-like receptor 5 LOC339453 1p36.33 hypothetical LOC339453 HSPC182 1p36.33 HSPC182 protein
    RNA
    TRANSCRIPTS type messenger
    text six rare spliced variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2941 - 670 - 1996 8817329
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain    
    Olfactory (smell)olfactory bulb     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Muscularstriatumcardiac  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Olfactoryolfactory receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text fetal brain, lung, liver and kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal DSH/DIX motif
  • one DEP domain
  • a Dlg, Discs-large suppressor tumor protein (DHR/GLGZ/PDZ) motif
  • C-terminal region (DVL1(DEP+)) interacts with APC , C terminus of DVL1 contains a number of proline-rich clusters
  • conjugated PhosphoP
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila dishevelled segment polarity gene 1
    homolog to murine Dvl1 (94.9pc)
    homolog to C.elegans t05c12.6a
    homolog to rattus Dvl1 (95.1pc)
    intraspecies homolog to DVL3
    Homologene
    FAMILY
  • DSH family
  • CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • activated in WNT signal transduction
  • putatively involved in neural and heart development
  • regulates cell proliferation, acting as a transducer molecule for developmental processes including segmentation and neuroblast specification
  • is required for LRP6 phosphorylation and aggregation after WNT treatment
  • involved in axon differentiation mediated by the PAR3-PAR6-aPKC complex
  • may play a role in the signal transduction pathway mediated by multiple Wnt genes
  • may contribute to the progression of NSCLCs
  • may be related to prostate cancer progression through the Wnt/beta-catenin pathway
  • inducing phosphorylation of MARK2 and thus regulating its membrane localization
  • DVL1, DVL2, DVL3 are core components in the correct routing and transmission of canonical and non-canonical Wnt signals, most likely by acting in large multiprotein complexes
  • with APC mediate a WNT5A-FZD2 signal to focal adhesions to regulate cell-substrate adhesions and migration
  • is a key regulator of both the canonical Wnt and the planar cell polarity (PCP) pathway
  • important determinants of Olfactory sensory neurons (OSNs) cell differentiation and axon extension
  • cytoplasmic protein which plays pivotal roles in the embryonic development
  • association of DVL1 and DVL3 with Hirschsprung disease (HSCR), it may play an important role in the pathogenesis of HSCR
  • may be an underlying participant of oxidative stress induced by selenium deficiency
  • is a central mediator of Wnt signal transduction
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    WNT7A-DVL1 signaling is required for spine morphogenesis and glutamatergic transmission in the hippocampus
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with myristoilated NKD2 at the plasma membrane, this interaction leading to their mutual ubiquitin-mediated proteasomal degradation
  • interacting with CXXC4, NXN, BRD7, INVS, VANGL1, VANGL2, CCDC88C/DAPLE, ARRB1
  • interacting with PI4K2A and forming a ternary complex with PIP5KI upon WNT3A stimulation
  • interacting with SMAD1 and thus coupling WNT and BMP signaling pathways
  • bound to APC directly and this complex played a role in the WNT5A-dependent formation of cell-substrate adhesions and polarized cell migration
  • VANGL2 promotes Wnt/planar cell polarity-like signaling by antagonizing DVL1-mediated feedback inhibition in growth cone guidance
  • required for WNT7A function
  • NEDD4 mediates the ubiquitylation and degradation of the adapter protein dishevelled-1 (DVL1), the expression of which negatively regulates cell-cell contact
  • ITCH is a DVL1-binding protein (ITCH ubiquitinates the phosphorylated form of DVL1 and promotes its degradation via the proteasome pathway, thereby inhibiting canonical Wnt signaling)
  • regulates precoupling of heterotrimeric G proteins to FZD6
  • DVL1 is a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity
  • cell & other
    REGULATION
    Other
  • interaction with INVS is required for ubiquitination
  • ASSOCIATED DISORDERS
    corresponding disease(s) DEL1P36 , RBNSOS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expressed in non-small cell lung cancer, positive expression correlated with pTNM stages and significantly higher in nodal metastases than in primary growths
    tumoral     --over  
    overexpressed in prostate cancer, expression level increasing with worsening histological grade
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for neuroblastomatous transformation
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
    DVL1 small murine