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FLASH GENE
Symbol DUT contributors: - updated : 20-07-2006
HGNC name dUTP pyrophosphatase
HGNC id 3078
Location 15q15-q21.1      Physical location : 48.623.620 - 48.635.568
Synonym name
  • dUTP nucleotidohydrolase
  • deoxyuridine 5'-triphosphate nucleotidohydrolase
  • Synonym symbol(s) FLJ20622, dUTPase
    EC.number 3.6.1.23
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2146 - 252 - Studebaker
    mitochondrial
    - - 1874 - 164 - Studebaker
    nuclear
    - - 1830 - 141 - Studebaker
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Respiratorylung   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION involved in nucleotide metabolism: producing dUMP, the immediate precursor of thymidine nucleotides and
    decreasing the intracellular concentration of dUTP so
    that uracil cannot be incorporated into DNA
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    Magnesium
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS