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FLASH GENE
Symbol DUSP9 contributors: mct - updated : 07-03-2007
HGNC name dual specificity phosphatase 9
HGNC id 3076
Location Xq28      Physical location : 152.907.896 - 152.916.780
Synonym name
  • mitogen activated protein kinase (MAPK) phosphatase 9
  • map kinase phosphatase 4
  • serine/threonine specific protein phosphatase
    • Synonym symbol(s) MKP4, MKP-4
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivefemale systemplacenta   
    Skin/Tegumentskin    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text only in placenta, kidney and embryonic liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • a rhodanese domain
  • a tyrosine-protein phosphatase domain
    • HOMOLOGY
    Homologene
    FAMILY dual specificity protein phosphatase subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inactivating target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in insulin-sensitive tissues during their differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate for the regulation of the stress responses involved in insulin resistance
    Marker
    Therapy target may provide a therapeutic target for treatment of type 2 diabetes
    ANIMAL & CELL MODELS