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FLASH GENE
Symbol DUSP3 contributors: mct - updated : 28-09-2016
HGNC name dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
HGNC id 3069
Location 17q21      Physical location : 41.843.489 - 41.856.368
Synonym name
  • Vaccinia virus VH1-related dual-specific protein phosphatase
  • mitogen activated protein kinase (MAPK) phosphatase 3
  • serine/threonine specific protein phosphatase
  • vaccinia virus phosphatase VH1-related
  • Synonym symbol(s) PTPV, VHR
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 9.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map see BRCA1 BRCA1
    Physical map
    ARHN 17q21 ras homolog gene family, member N BRCA1 17q21 breast cancer 1, early onset RPL21P4 17q21 ribosomal protein L21 pseudogene 4 NBR2 17q21 neighbor of BRCA1 gene 2 LOC387620 17 membrane component, chromosome 17, surface marker 2 MGC20235 17q21.31 hypothetical protein MGC20235 LOC388388 17 LOC388388 RNU2P2 17q21.31 RNA, U2 small nuclear pseudogene 2 ARF4L 17q12-q21 ADP-ribosylation factor 4-like LOC284064 17q21.31 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) DHX8 17q21.31 DEAH (Asp-Glu-Ala-His) box polypeptide 8 ETV4 17q21 ets variant gene 4 (E1A enhancer binding protein, E1AF) MEOX1 17q21 mesenchyme homeo box 1 LOC390797 17 similar to WHSC1L1 protein isoform long; Wolf-Hirschhorn syndrome candidate 1-like 1 protein SOST 17q12-q21 sclerosteosis DUSP3 17q21 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) LOC284067 17q21.31 hypothetical LOC284067 MPP3 17q12-q21 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) TREM4 17q21.31 triggering receptor expressed on myeloid cells 4 MPP2 17q12-q21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) APR-2 17q21.31 apoptosis related protein LOC390798 17 similar to wingless-type MMTV integration site family, member 9B precursor; wingless-type MMTV integration site family, member 15 PPY 17q21.2 pancreatic polypeptide PYY 17q21.1 peptide YY NAGS 17q21.31 peptide YY MGC4251 17q21.31 hypothetical protein MGC4251 FLJ30656 17q21.31 hypothetical protein FLJ30656 G6PC3 17q21.31 glucose-6-phosphatase catalytic subunit 3 HDAC5 17q21 histone deacetylase 5 MGC3130 17q21.31 hypothetical protein MGC3130 ASB16 17q21.31 ankyrin repeat and SOCS box-containing 16 DKFZp762C2414 17q21.31 hypothetical protein DKFZp762C2414 MGC3123 17q21.31 hypothetical protein MGC3123 UBTF 17q21.3 upstream binding transcription factor, RNA polymerase I LOC390799 17 similar to SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1 SLC4A1 17q21-q22 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) RPIP8 17p13.2 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) CGI-69 17q12 CGI-69 protein GRN 17q21.3 granulin MGC34829 17q21.31 Similar to hypothetical gene supported by AL050367; AK022946 LOC390800 17 similar to ribosomal protein L7-like 1 ITGA2B 17q21.32 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) KIAA0553 17q21.31 KIAA0553 protein
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreast   
     female systemovary   
     female systemuteruscervix  
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • a tyrosine-protein phosphatase domain
  • HOMOLOGY
    intraspecies homolog to vaccinia virus phosphatase VH1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate
  • inactivating the mitogen-activated kinases ERK2 and MAPK8
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target for ZAP70 and tempers activation of the ERK2 pathway in a ZAP70-controlled manner
  • VRK3 enhances the phosphatase activity of DUSP3 by a mechanism independent of its kinase activity, and direct interaction of DUSP3 with VRK3 posttranslationally regulates ERK signalling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS