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FLASH GENE
Symbol DUSP3 contributors: mct - updated : 28-09-2016
HGNC name dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
HGNC id 3069
Location 17q21      Physical location : 41.843.489 - 41.856.368
Synonym name
  • Vaccinia virus VH1-related dual-specific protein phosphatase
  • mitogen activated protein kinase (MAPK) phosphatase 3
  • serine/threonine specific protein phosphatase
  • vaccinia virus phosphatase VH1-related
  • Synonym symbol(s) PTPV, VHR
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 9.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map see BRCA1 BRCA1
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreast   
     female systemovary   
     female systemuteruscervix  
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • a tyrosine-protein phosphatase domain
  • HOMOLOGY
    intraspecies homolog to vaccinia virus phosphatase VH1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate
  • inactivating the mitogen-activated kinases ERK2 and MAPK8
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target for ZAP70 and tempers activation of the ERK2 pathway in a ZAP70-controlled manner
  • VRK3 enhances the phosphatase activity of DUSP3 by a mechanism independent of its kinase activity, and direct interaction of DUSP3 with VRK3 posttranslationally regulates ERK signalling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS