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FLASH GENE
Symbol DUSP23 contributors: - updated : 15-02-2006
HGNC name dual specificity phosphatase 23
HGNC id 21480
Location 1q23.2      Physical location : 159.750.758 - 159.752.333
Synonym name
  • VH1-like member Z
  • low-molecular-mass dual-specificity phosphatase 3
  • Synonym symbol(s) DUSP25, FLJ20442, LDP-3, RP11-190A12.1, VHZ
    DNA
    TYPE functioning gene
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivemale systemtestis   
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • a dual-specificity phosphatase catalytic (DSPc) domain
  • residues C-terminal to the TY motif may represent determinants of DUSP23 substrate specificity
  • HOMOLOGY
    Homologene
    FAMILY intracellular, non-receptor VH1-like, atypical dual specificity phosphatases subfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in the regulation of mitogenic signal transduction and controlling the cell cycle in response to extracellular stimuli
  • protein phosphatase with dual substrate specificity
  • single domain, globular protein, mediating dephosphorylation of phospho-tyrosyl (pTyr) and phospho-seryl/threonyl (pSer/pThr) residues in specific proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS