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Symbol DUSP21 contributors: npt - updated : 09-12-2009
HGNC name dual specificity phosphatase 21
HGNC id 20476
Location Xp11.3      Physical location : 44.703.248 - 44.704.132
Synonym name
  • low molecular weight dual specificity phosphatase 21
  • BJ-HCC-26 tumor antigen
  • Synonym symbol(s) LMWDSP21, MGC149878
    EC.number 3.1.3.48, 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 0.88 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 889 - 190 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DSP motif
  • HOMOLOGY
    intraspecies homolog to DUSP14
    Homologene
    FAMILY
  • dual specificity phosphatase (DSP) family
  • non-receptor class dual specificity subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • protein serine/threonine phosphatase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is able to act against ERK, JNK, and p38 MAPKs
  • cell & other
    REGULATION
    inhibited by sodium orthovanadate, in vitro
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS