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FLASH GENE
Symbol DUSP2 contributors: mct - updated : 06-01-2010
HGNC name dual specificity phosphatase 2
HGNC id 3068
Location 2q11.2      Physical location : 96.808.916 - 96.811.179
Synonym name
  • mitogen activated protein kinase (MAPK) phosphatase 2
  • dual specificity protein phosphatase PAC-1
  • serine/threonine specific protein phosphatase
  • Synonym symbol(s) PTPVL2, PAC1
    EC.number 3.1.3.48, 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 2.27 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    motif repetitive sequence   other
    text structure palindromic site in the promoter
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1708 34.3 314 - 2007 17471234
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage hematopoietic cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • negative regulator of mitogen activated protein (MAP) kinase family
  • playing a role necessary and sufficient for TP53 -induced apoptosis and growth suppression
  • inducible, nuclear-specific, dual-specificity mitogen-activated protein (MAP) kinase phosphatase that is a transcription target of TP53 in signaling apoptosis and growth suppression
  • involved in ERK2 dephosphorylation, requiring association of its N-terminal domain with ERK2 that results in catalytic activation of the phosphatase
  • having a crucial role in E2F1-directed apoptosis
  • involved in stimulus-specific, and phosphatase-specific mechanism of MAPK1 regulation in the nucleus
  • with DUSP1, and DUSP10 are crucial players in the regulation of immune responses, but other members of the family, like the ERK-specific DUSP6, play a major role in development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inactivating ERK1, ERK2
  • direct transcription target of E2F1 in signaling apoptosis
  • cell & other
    REGULATION
    activated by TP53 during apoptosis
    induced by in response to serum deprivation and oxidative stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS