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FLASH GENE
Symbol DUSP19 contributors: npt - updated : 09-12-2009
HGNC name dual specificity phosphatase 19
HGNC id 18894
Location 2q32.1      Physical location : 183.943.286 - 183.964.720
Synonym name
  • protein phosphatase
  • stress-activated protein kinase pathway-regulating phosphatase 1
  • SAPK pathway-regulating phosphatase 1
  • Synonym symbol(s) SKRP1, DUSP17, TS-DSP1, LMW-DSP3, MGC138210
    EC.number 3.1.3.48, 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 21.02 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 5379 - 217 - -
    3 - 5226 - 166 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveliver    
    Endocrinepancreas   highly
    Reproductivemale systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text kidney, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single dual specificity phosphatase catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Dusp19
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family. non-receptor class dual specificity subfamily
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having a protein-tyrosine phosphatase activity toward oligopeptides containing pSer/Thr and pTyr, indicating that it is a protein phosphatase with dual substrate specificity
  • negatively regulating the activation of the JNK pathway
  • increases the MAP3K5-MAP2K7 complexes and enhances the activation of MAP2K7 by MAP3K5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with its substrate JNK via MAP2K7, leading to the regulation of the substrate
  • interacts with MAP3K5
  • cell & other
    REGULATION
    inhibited by sodium vanadate, in vitro
    Other activity is enhanced by Ca2+ and Mn2+
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS