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FLASH GENE
Symbol DUSP18 contributors: npt - updated : 10-12-2009
HGNC name dual specificity phosphatase 18
HGNC id 18484
Location 22q12.2      Physical location : 31.058.038 - 31.063.872
Synonym name
  • dual-specificity phosphatase 18
  • low molecular weight dual specificity phosphatase 20
  • Synonym symbol(s) DUSP20, LMWDSP20, MGC32658, bK963H5.1, DSP18
    EC.number 3.1.3.16, 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 5.83 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MTMR3 22q12.2 myotubularin related protein 3 LOC391326 22 similar to h2-calponin MGC26710 22q12.2 hypothetical protein MGC26710 LIF 22q12.2 leukemia inhibitory factor (cholinergic differentiation factor) OSM 22q12.2 oncostatin M TBC1D10 22q12.1-qter TBC1 domain family, member 10 SF3A1 22q12.1 splicing factor 3a, subunit 1, 120kDa LOC388891 22 similar to hypothetical protein 4930562D19 LOC200312 22q12.2 similar to RIKEN cDNA 0610009J22 SEC14L2 22q12.2 SEC14-like 2 (S. cerevisiae) HSPC242 22q hypothetical protein HSPC242 LOC391327 22 similar to solute carrier family 39 (zinc transporter), member 1; zinc-iron regulated transporter-like gene; solute carrier family 39 (zinc transporter), member 3; zinc/iron regulated transporter-like SEC14L3 22q12.2 SEC14-like 3 (S. cerevisiae) LOC376844 SEC14L4 22q12.1 SEC14-like 4 (S. cerevisiae) PTPNS1L 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like CST 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like PES1 22q12.2 pescadillo homolog 1, containing BRCT domain (zebrafish) TCN2 22q12.2 transcobalamin II; macrocytic anemia SLC35E4 22q12.2 solute carrier family 35, member E4 LOC391328 22 similar to tum- transplantation antigen P198 DUSP18 22q12.1 dual specificity phosphatase 18 OSBP2 22q12.2 oxysterol binding protein 2 FLJ35801 22q12.2 hypothetical protein FLJ35801 ZCWCC1 22q12.2 zinc finger, CW-type with coiled-coil domain 1 FLJ20618 22q12.2 hypothetical protein FLJ20618 LOC388893 22 LOC388893 SMTN 22q12.2 smoothelin SELM 22q12.2 selenoprotein SelM PIB5PA 22q12.2 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A PLA2G3 22q11.2-q13.2 phospholipase A2, group III FLJ38628 22q12.3 hypothetical protein FLJ38628 AGTRL2 22q12.2 angiotensin II receptor-like 2 LIMK2 22q12.2 LIM domain kinase 2 PPP1R14BP1 22q12 protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 1 MGC17330 22q12.2 HGFL gene ZNF278 22q12.2 zinc finger protein 278 MGC15705 22q12.3 hypothetical protein MGC15705
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2453 - 188 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text brain, placenta
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • DSP domain
  • HOMOLOGY
    interspecies homolog to murine Dusp18
    intraspecies homolog to DUSP14
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • protein tyrosine phosphatase activity
  • serine/threonine phosphatase activity
  • is able to act against ERK, JNK and p38 MAPKs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERK, JNK, p38
  • cell & other
    REGULATION
    inhibited by iodoaretic acid, Naf and EDTA in vitro
    Other enzymatic activity enhanced by Mn2+ ions in vitro
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS