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FLASH GENE
Symbol DUSP18 contributors: npt - updated : 10-12-2009
HGNC name dual specificity phosphatase 18
HGNC id 18484
Location 22q12.2      Physical location : 31.058.038 - 31.063.872
Synonym name
  • dual-specificity phosphatase 18
  • low molecular weight dual specificity phosphatase 20
    • Synonym symbol(s) DUSP20, LMWDSP20, MGC32658, bK963H5.1, DSP18
    EC.number 3.1.3.16, 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 5.83 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2453 - 188 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text brain, placenta
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • DSP domain
    • HOMOLOGY
    interspecies homolog to murine Dusp18
    intraspecies homolog to DUSP14
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • protein tyrosine phosphatase activity
  • serine/threonine phosphatase activity
  • is able to act against ERK, JNK and p38 MAPKs
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERK, JNK, p38
    • cell & other
    REGULATION
    inhibited by iodoaretic acid, Naf and EDTA in vitro
    Other enzymatic activity enhanced by Mn2+ ions in vitro
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS