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FLASH GENE
Symbol DUSP15 contributors: - updated : 18-03-2006
HGNC name dual specificity phosphatase-like 15
HGNC id 16236
Location 20q11.21      Physical location : 30.448.869 - 30.458.479
Synonym name VH1-related member Y
Synonym symbol(s) bA243J16.6, RP11-243J16.11, VHY
EC.number 3.1.3.16, 3.1.3.48
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1383 - 235 - Deloukas et al.(01)
longer isoform
- - 1184 - 132 - Deloukas et al. (01)
Differs in the 5' UTR and coding region compared to variant 1, resulting in isoform b with a shorter N-terminus compared to isoform a
- - 1212 - 132 - Alonso
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid    
Nervousbrain    
Reproductivemale systemtestis   
 male systemprostate   
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveLeydig cell
Reproductivespermatid
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an N-terminal myristoylation recognition sequence
HOMOLOGY
interspecies homolog to murine Dusp15
intraspecies homolog to DUSP22
Homologene
FAMILY non receptor class of the protein-tyrosine phosphatase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,nucleus
text in pachytene spermatocytes (midstage of meiotic division I)
basic FUNCTION
  • protein-tyrosine phosphatase activity
  • serine/threonine-specific phosphatase activity
  • new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS