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FLASH GENE
Symbol DUSP15 contributors: - updated : 18-03-2006
HGNC name dual specificity phosphatase-like 15
HGNC id 16236
Location 20q11.21      Physical location : 30.448.869 - 30.458.479
Synonym name VH1-related member Y
Synonym symbol(s) bA243J16.6, RP11-243J16.11, VHY
EC.number 3.1.3.16, 3.1.3.48
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391241 20 similar to Soggy-1 protein precursor (SGY-1) LOC149935 20q11.21 similar to CDK5 regulatory subunit associated protein 3; CDK5 activator-binding protein C53; ischemic heart CDK5 activator-binding protein C53 RPL31P3 20p11-q11 ribosomal protein L31 pseudogene 3 DEFB118 20q11.1-q11.22 defensin, beta 118 DEFB119 20q11.1 defensin, beta 119 DEFB123 20q11.1 defensin, beta 123 REM 20q11.1 RAS (RAD and GEM)-like GTP-binding LOC388794 20 similar to dJ1093G12.6 (A novel protein) HM13 20q11.21 histocompatibility (minor) 13 ID1 20q11 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein COX4I2 20q11.21 cytochrome c oxidase subunit IV isoform 2 BCL2L1 20q11.1 BCL2-like 1 TPX2 20q11.2 TPX2, microtubule-associated protein homolog (Xenopus laevis) MYLK2 20q13.31 myosin light chain kinase 2, skeletal muscle FKHL18 20q11.1-q11.2 forkhead-like 18 (Drosophila) DUSP15 20 dual specificity phosphatase-like 15 LOC164395 20q11.21 hypothetical protein LOC164395 C20orf126 20q11.21 chromosome 20 open reading frame 126 LOC343702 20q11.21 similar to dJ310O13.4 (novel protein similar to predicted C. elegans and C. intestinalis proteins) C20orf160 20q11.2 chromosome 20 open reading frame 160 HCK 20q11.21 hemopoietic cell kinase TM9SF4 20q11.21 transmembrane 9 superfamily protein member 4 RPL24P1 20q11 ribosomal protein L24 pseudogene 1 TSPYL3 20q11.1 TSPY-like 3 PLAGL2 20q11.1 pleiomorphic adenoma gene-like 2 POFUT1 20q11 protein O-fucosyltransferase 1 KIF3B 20p11.2-q11.21 kinesin family member 3B ASXL1 20q11 additional sex combs like 1 (Drosophila) DKFZP566G1424 20q11.1-q11.23 hypothetical protein DKFZp566G1424 C20orf112 20q11.1-q11.23 chromosome 20 open reading frame 112 LOC284804 20q11.21 hypothetical protein LOC284804 LOC149950 20q11.21 hypothetical LOC149950 FLJ33706 20q11.22 hypothetical protein FLJ33706 C20orf92 20q11.22 chromosome 20 open reading frame 92
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1383 - 235 - Deloukas et al.(01)
longer isoform
- - 1184 - 132 - Deloukas et al. (01)
Differs in the 5' UTR and coding region compared to variant 1, resulting in isoform b with a shorter N-terminus compared to isoform a
- - 1212 - 132 - Alonso
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid    
Nervousbrain    
Reproductivemale systemtestis   
 male systemprostate   
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveLeydig cell
Reproductivespermatid
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an N-terminal myristoylation recognition sequence
HOMOLOGY
interspecies homolog to murine Dusp15
intraspecies homolog to DUSP22
Homologene
FAMILY non receptor class of the protein-tyrosine phosphatase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,nucleus
text in pachytene spermatocytes (midstage of meiotic division I)
basic FUNCTION
  • protein-tyrosine phosphatase activity
  • serine/threonine-specific phosphatase activity
  • new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS