Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DUSP14 contributors: mct - updated : 26-08-2014
HGNC name dual specificity phosphatase 14
HGNC id 17007
Location 17q12      Physical location : 35.849.950 - 35.873.588
Synonym name MKP-1 like protein tyrosine phosphatase
Synonym symbol(s) MKP-L, MKP6
EC.number 3.1.3. 16, 3.1.3.48
DNA
TYPE functioning gene
STRUCTURE 23.65 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388369 17 LOC388369 LOC388370 17 similar to cytokine LOC388371 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC390788 17 similar to CCL3L1 protein CCL3L1 17q11.2 chemokine (C-C motif) ligand 3-like 1 LOC388372 17 similar to cytokine LOC388373 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388374 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) TRIP3 17q21.1 thyroid hormone receptor interactor 3 FLJ22865 17q21.1 hypothetical protein FLJ22865 PIGW 17q21.1 phosphatidylinositol glycan, class W LZK1 17q21.1 C3HC4-type zinc finger protein MGC4172 17q21.1 hypothetical protein MGC4172 FLJ22578 17q21.1 hypothetical protein FLJ22578 LOC388375 17 LOC388375 LOC388376 17 LOC388376 LHX1 11p13-p12 LIM homeobox protein 1 AATF 17q11.2-q12 apoptosis antagonizing transcription factor ACACA 17q21 acetyl-Coenzyme A carboxylase alpha FLJ39647 17q21.1 hypothetical protein FLJ39647 TADA2L 17q12-q21 transcriptional adaptor 2 (ADA2 homolog, yeast)-like DUSP14 17q12 dual specificity phosphatase 14 AP1GBP1 17p13.2 AP1 gamma subunit binding protein 1 DDX52 17q21.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 TCF2 17q11.2-q12 transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor LOC388377 17 similar to MLL/AF10 fusion protein UPN9610I LOC388378 17 similar to TBC1 domain family, member 3; Rab GTPase-activating protein PRC17; prostate cancer gene 17 TBC1D3 17q21.2 TBC1 domain family, member 3 LOC388379 17 similar to Puromycin-sensitive aminopeptidase (PSA) MRPL45 17q21.2 mitochondrial rbosomal protein L45 LOC342663 17q21.1 similar to mKIAA1136 protein NAP4 17q21.1 Nck, Ash and phospholipase C binding protein LOC388380 17 LOC388380 KIAA1501 17q21.1-q21.2 KIAA1501 protein KIAA1684 17q21.2 likely homolog of mouse p140 LOC390789 17 similar to RIKEN cDNA E130012A19 MLLT6 17q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 RNF110 12-12q22 ring finger protein 110 PSMB3 2q35 proteasome (prosome, macropain) subunit, beta type, 3 PIP5K2B 17q12 phosphatidylinositol-4-phosphate 5-kinase, type II, beta FLJ20291 17q21.2 hypothetical protein FLJ20291
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1508 - 198 - 2009 19770498
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinethyroid   highly
Respiratoryrespiratory tracttrachea  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text highly in placenta and fetal lung, thymus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved centrally catalytic core
  • a single catalytic phosphatase domain
  • HOMOLOGY
    interspecies homolog to murine Dusp14
    Homologene
    FAMILY MKP family, non receptor class dual specificity subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • negative regulator of CD28 signaling
  • tyrosine/serine/threonine phosphatase activity
  • hydrolase activity
  • dephosphorylates ERK, JNK, MAPK14
  • is a negative regulator of TNF- and IL1-induced NFKB1 activation
  • negatively regulates TCR signaling and immune responses by inhibiting TAB1 activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CD28, ERK, JNK, MAPK14
  • negative regulator of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, rapidly and strongly activated by GCG
  • interacted with MAP3K7 and this interaction was enhanced by TNF or IL1 stimulation
  • directly interacted with MAP3K7-binding protein 1 (TAB1) and dephosphorylated TAB1 at Ser(438), leading to TAB1-MAP3K7 complex inactivation in T cells
  • acts as a MAP3K7 phosphatase to negatively regulate TNF- and IL1-induced NFKB1 activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS