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FLASH GENE
Symbol DUSP13 contributors: mct/npt - updated : 02-06-2010
HGNC name dual specificity phosphatase 13
HGNC id 19681
Location 10q22.2      Physical location : 76.854.191 - 76.868.970
Synonym name
  • protein phosphatase
  • likely ortholog of mouse dual specificity phosphatase 13
  • testis and skeletal muscle-specific dual specificity phosphatase
  • dual-specificity phosphatase SKRP4
  • muscle-restricted dual specificity phosphatase
  • branching-enzyme interacting dual-specificity protein
  • phosphatase
    Synonym symbol(s) BEDP, TMDP, FLJ32450, MDSP, TS-DSP6, DUSP13A, DUSP13B
    EC.number 3.1.3.16, 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 14.78 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SEC24C 10q22.3 SEC24 related gene family, member C (S. cerevisiae) FUT11 10q22.3 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) LOC118487 10q22.3 similar to RIKEN cDNA 1110001O19 LOC196752 10q22.3 similar to CG32542-PA KIAA0913 10q22.3 KIAA0913 protein NDST2 10q22 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 CAMK2G 10q22.3 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma PLAU 10q23.3-q24.3 plasminogen activator, urokinase VCL 10q22.1-q23 vinculin AP3M1 10q22.3 adaptor-related protein complex 3, mu 1 subunit ADK 10q22.3 adenosine kinase MRPL35P3 10q22.2 adenosine kinase LOC389979 10 similar to hypothetical protein DKFZp586O0120.1 - human (fragment) MYST4 10q22.2 MYST histone acetyltransferase (monocytic leukemia) 4 DUPD1 10q22.3 dual specificity phosphatase and pro isomerase domain containing 1 DUSP13 10q22.3 dual specificity phosphatase 13 SAMD8 10q22.3 sterile alpha motif domain containing 8 VDAC2 10q22 voltage-dependent anion channel 2 FLJ23841 10q22.3 hypothetical protein FLJ23841 LOC387687 10 LOC387687 SPA17P1 10q22.3 sperm autoantigenic protein 17 pseudogene 1 ZNF503 10q22.3 zinc finger protein 503 LOC283065 10q22.3 hypothetical gene supported by BC017426 LOC387688 10 LOC387688 CDA017
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1788 - 188 restricted to muscle Chen (2004)
    also called variant 1 or MDSP
    4 - 1063 - 248 - Chen (2004)
    also called variant 2 or TMDP-L2
    6 - 1362 - 291 - Chen (2004)
    also called variant 3 or TMDP-L1
    4 - 923 - 198 - Chen (2004)
    also called variant 6 or TDMP
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to murine Dusp13
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • may be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis
  • exhibiting intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues
  • of myelin basic protein
  • implicated as major modulators of critical signalling pathways that are dysregulated in various diseases (Patterson 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS