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FLASH GENE
Symbol DUSP11 contributors: - updated : 05-05-2006
HGNC name dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
HGNC id 3066
Location 2p13.1      Physical location : 73.989.325 - 74.007.284
Synonym name
  • phosphatase that interacts with RNA/RNP complex 1
  • serine/threonine specific protein phosphatase
  • RNA/RNP complex-interacting phosphatase
  • Synonym symbol(s) PIR1
    EC.number 3.1.3.16, 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 17.96 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GAF1 2p13-p12 gamma-SNAP-associated factor 1 LOC344022 2p13.2 similar to Gnot1 homeodomain protein SMYD5 2p12 SMYD family member 5 C2orf7 2p12 chromosome 2 open reading frame 7 CCT7 2p13.2 chaperonin containing TCP1, subunit 7 (eta) EGR4 2p13 early growth response 4 LOC391387 2 similar to protein 40kD ALMS1 2p13 Alstrom syndrome 1 NAT8 2p13-1-p12 N-acetyltransferase 8 (camello like) LOC200420 2p13.1 LOC200420 CML2 2p13.1 putative N-acetyltransferase Camello 2 CGI-121 2p24.3-p24.1 CGI-121 protein DUSP11 2p13 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) LOC388960 2 similar to hypothetical protein 4921507A12 AMSH ACTG2 2p13.1 actin, gamma 2, smooth muscle, enteric DGUOK 2p24.3-p24.1 deoxyguanosine kinase LOC388961 2 LOC388961 MGC22014 2p13.1 hypothetical protein MGC22014 MGC10955 2p13.1 hypothetical protein MGC10955 LOC388962 2 similar to RIKEN cDNA 1810056O20 C2orf6 2p12 chromosome 2 open reading frame 6 MTHFD2 2p12 methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase SLC4A5 2p13 solute carrier family 4, sodium bicarbonate cotransporter, member 5 DCTN1 2p13 dynactin 1 (p150, glued homolog, Drosophila) LOC388963 2 similar to Retinol dehydrogenase 12 LOC257200 2p13.1 similar to high mobility group AT-hook 1 FLJ12953 2p13.1 hypothetical protein FLJ12953 similar to Mus musculus D3Mm3e RTKN 2p13 rhotekin
    regionally located in the region of PARK3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1639 - 377 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage epidermoid and myeloblastic cell lineages
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved motif at the catalytic site
  • two stretches of arginine-rich sequence
  • a proline-rich region
  • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text colocolizing in nuclear speckles with the splicing factor SC35
    basic FUNCTION
  • regulating negatively the members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK,SAPK/JNK,p38) which is associated with cellular proliferation and differentiation
  • participating in nuclear mRNA metabolism
  • playing important roles in signal transduction,cell cycle progression and tumor suppression
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    nuclear mRNA metabolism
    a component
  • associated with RNA and/or RNP complexes
  • INTERACTION
    DNA binding to single strand
    RNA binding
    small molecule
    protein
  • binding to RNP complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS