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FLASH GENE
Symbol DUSP10 contributors: mct - updated : 08-02-2012
HGNC name dual specificity phosphatase 10
HGNC id 3065
Location 1q41      Physical location : 221.874.765 - 221.915.461
Synonym name
  • dual specificity phosphatase MKP-5
  • map kinase phosphatase 5
  • mitogen-activated protein kinase phosphatase 5
  • Synonym symbol(s) MKP5, MKP-5
    EC.number 3.1.3.16, 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 40.75 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D1S474 - D1S229 - TGFB2 - D1S2880 - D1S2894 - DUSP10 - ITPKB - D1S479 - D1S439 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2619 52.5 482 - 2007 17681939
    3 - 2244 16 140 - 2007 17681939
    3 - 1765 16 140 - 2007 17681939
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Nervousnerve   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal region of unknown function
  • two Cdc 25 homology 2 domains in the middle
  • a C terminal catalytic domain, as well as a binding domain (BD) that help recognize the target MAP kinase
  • secondary structure
  • cluster of positively charged AAs important for MAP kinase binding is alpha-helical
  • HOMOLOGY
    Homologene
    FAMILY
  • mitogen-activated protein kinase phosphatase (MKP) family
  • non-receptor class dual specificity subfamily
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • having a principal function in both innate and adaptive immune responses
  • inactivating p38 and SAPK/SNK kinases
  • coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress
  • earlier unrecognized and non-redundant function in restraining MAPK14-mediated neutrophil oxidant production, thereby preventing LPS-induced vascular injury
  • with DUSP2, and DUSP1 are crucial players in the regulation of immune responses, but other members of the family, like the ERK-specific DUSP6, play a major role in development
  • key regulator in PYCARD-dependent MAPK activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DUSP10 is a novel PYCARD target
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS