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FLASH GENE
Symbol DUOXA1 contributors: mct - updated : 20-04-2007
HGNC name dual oxidase maturation factor 1
HGNC id 26507
Location 15q15.3      Physical location : 45.409.687 - 45.422.057
Synonym name
  • dual oxidase activator 1
  • numb-interacting protein
    • Synonym symbol(s) NIP, mol, NUMBIP, FLJ32334
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text head to head to DUOX1 in the 16-kbp DUOX1/DUOX2 intergenic region
    STRUCTURE 12.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1923 53 483 - Grasberger
    - - 1044 - 353 - Grasberger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
    Endocrinethyroid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Kozak consensus domain
  • five membrane integral region
  • three NX (S/T) consensus site for N glycosylation clustered within an external connecting the second and third transmembrane helices
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila numb
    Homologene
    FAMILY
  • NADPH oxydase family
  • DUOXA family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text ER-resident transmembrane protein
    basic FUNCTION
  • allowing ER-to-Golgi transition, maturation, and translocation to the plasma membrane of functional DUOX2 in a heterologous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein DUOX1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS