| basic FUNCTION
| catalyzing the synthesis of thyroid hormone |
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essential for iodination of thyroglobulin by thyroid peroxidase and constitutes the rate-limiting step of thyroid hormone synthesis |
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dual oxydase constitute the catalytic core of the H2O2 generator |
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exhibiting potent heme peroxidase activity in human respiratory tract epithelium |
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NADPH oxidases producing H(2)O(2) necessary for thyroid hormone biosynthesis  |
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with NOX4, are required for platelet-derived growth factor (PDGF) induced RB1 phosphorylation in normal fibroblasts |
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NOX4 and DUOX2 regulate cell cycle entry as part of a p53-dependent checkpoint for proliferation |
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both DUOX1 and DUOX2 play a critical role in the production of H2O2 in the thyroid gland, which is the limiting factor in thyroglobulin iodination and thyroxine synthesis |
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despite the high sequence similarity shared between DUOX1 and DUOX2, the two isoforms present distinct regulations, tissue expression and catalytic functions |
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both DUOX2 and DUOXA2 expression are involved specifically in inflammation and are regulated on a crypt-by-crypt basis in ulcerative colitis tissue |
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both stability and function of the maturation factor, DUOXA2, are dependent on the oxidative folding of DUOX2, indicating that DUOX2 displays a chaperone-like function with respect to its partner |
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both DUOX enzymes (DUOX1, DUOX2) and their respective maturation factors DUOXA1 and DUOXA2 form a stable complex at the cell surface, which is fundamental for their enzymatic activity |
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thyroid hormone synthesis requires H2O2, produced by two NADPH oxidases, DUOX1 and DUOX2 |
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H2O2 produced by the DUOX2/DUOXA2 cell surface enzymatic complex could provoke potential mutagenic DNA damage in an inducible cellular model |
