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FLASH GENE
Symbol DTX4 contributors: mct - updated : 01-12-2020
HGNC name deltex E3 ubiquitin ligase 4 homolog (Drosophila)
HGNC id 29151
Location 11q12.1      Physical location : 58.939.811 - 58.976.060
Synonym name related to rat S/T-protein kinase
Synonym symbol(s) KIAA0937, RNF155, MGC141899
EC.number 2.3.2.27
DNA
TYPE functioning gene
STRUCTURE 37.16 kb     9 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 5387 - 513 - 2017 28611181
9 - 6003 - 619 - 2017 28611181
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainhindbraincerebellum  
 brainbasal nuclei   
 spinal cord    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RING-type zinc finger
  • HOMOLOGY
    interspecies ortholog to murine Dtx4
    ortholog to rattus Dtx4
    Homologene
    FAMILY Deltex family of proteins
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • DTX4 protein expression gradually increased during adipogenic differentiation of 3T3-L1 preadipocytes cell line
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
  • DYRK2 phosphorylated Ser527 of TBK1, which is essential for the recruitment of NLRP4 and for the E3 ubiquitin ligase DTX4 to degrade TBK1
  • upon ligand binding, NOTCH1 at the cell surface was ubiquitylated by the E3 ubiquitin ligase DTX4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS