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FLASH GENE
Symbol DTX3L contributors: mct/npt - updated : 11-07-2015
HGNC name deltex 3-like (Drosophila)
HGNC id 30323
Location 3q21.1      Physical location : 122.283.184 - 122.294.047
Synonym name
  • B-lymphoma- and BAL-associated protein
  • rhysin-2
  • deltex 3-like
  • Synonym symbol(s) BBAP, Rhysin2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text located on chromosome 3q21 in a head-to-head orientation with PARP9 (Juszczynski 2006)
    STRUCTURE 10.01 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 5768 - 740 - Yan (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
    Reproductivefemale systembreastmammary gland  
    Respiratoryrespiratory tracttrachea   
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lacks the highly basic N-terminal motif and the central proline-rich motif present in other Deltex proteins, and instead contains other unique N-terminal domains
  • C-terminal region is highly homologous to that of DTX family members (Takeyama 2003), including a RING domain and a previously unidentified C-terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • Deltex family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • localizes to early endosomes upon CXCR4 activation
  • basic FUNCTION
  • function as E3 ligases based on its capacity for self-ubiquitination (Takeyama 2003)
  • regulates the subcellular localization of PARP9 by a dynamic shuttling mechanism, highlighting the functional requirement for coordinated DTX3L and PARP9 expression (Juszczynski 2006)
  • selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents (Yan 2009)
  • directly implicated in the monoubiquitylation and additional posttranslational modification of histone H4 and an associated DNA damage response (Yan 2009)
  • selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents
  • directly implicated in the monoubiquitylation and additional posttranslational modification of histone H4 and an associated DNA damage response
  • E3 ligase that regulates subcellular localization of its partner protein, PARP9, by a dynamic nucleocytoplasmic trafficking mechanism
  • selectively ubiquitylates histone H4 and indirectly promotes early TP53BP1 recruitment to DNA damage sites
  • DTX3L and PARP9 are bona fide members of a DNA damage response pathway and are directly associated with PARP1 activation, BRCA1 recruitment, and double-strand break repair
  • novel role for the really interesting new gene-domain E3 ubiquitin ligase deltex-3-like (DTX3L) in regulating CXCR4 sorting from endosomes to lysosomes
  • DTX3L and PARP9 act together as repressors of the tumor suppressor IRF1 in prostate cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexes with PARP9 (Juszczynski 2006)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DTX1 (DTX1 associate via their unique N termini, resulting in enhanced self-ubiquitination) (Takeyama 2003)
  • interacts directly with and inhibits the activity of the E3 ubiquitin ligase atrophin-1 interacting protein 4
  • cell & other
    REGULATION
    Other regulated by a IFN-gamma-responsive bidirectional promoter (Juszczynski 2006)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS