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FLASH GENE

Symbol

DSTN

contributors: - updated : 11-10-2005

HGNC name	destrin (actin depolymerizing factor)
HGNC id	15750

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20p11.23      Physical location : 17.550.598 - 17.588.651
Synonym name	destrin
Synonym symbol(s)	ADF,ACTDP,HGNC15750,bA462D18 2

DNA

TYPE	functioning gene
STRUCTURE	38.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed DSTN a - - 1614 DSTN b - splicing 1746 - 148 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Dstn

Homologene

FAMILY

actin-binding proteins ADF family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microfilament

basic FUNCTION

This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin).

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

actin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS