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FLASH GENE
Symbol DSTN contributors: - updated : 11-10-2005
HGNC name destrin (actin depolymerizing factor)
HGNC id 15750
Location 20p11.23      Physical location : 17.550.598 - 17.588.651
Synonym name destrin
Synonym symbol(s) ADF,ACTDP,HGNC15750,bA462D18 2
DNA
TYPE functioning gene
STRUCTURE 38.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PPIP11 20p12.1 peptidylprolyl isomerase (cyclophilin) pseudogene 11 C20orf23 20p11.23 chromosome 20 open reading frame 23 RPLP0P1 20p11.23 ribosomal protein, large, P0 pseudogene 1 RPL7AL3 20p11.23 ribosomal protein L7a-like 3 SNRPB2 20p12.2-p11.22 small nuclear ribonucleoprotein polypeptide B'' OTOR 20p12.1-p11.23 otoraplin PCSK2 20p11.2 proprotein convertase subtilisin/kexin type 2 BFSP1 20p11.23 beaded filament structural protein 1, filensin RPS27AP2 20p11.2 ribosomal protein S27a pseudogene 2 DSTN 20p11.23 destrin (actin depolymerizing factor) RRBP1 20p12-p11.2 ribosome binding protein 1 homolog 180kDa (dog) C20orf179 20 chromosome 20 open reading frame 179 SNX5 20pter-q11.23 sorting nexin 5 C20orf72 20p11.23 chromosome 20 open reading frame 72 PTMAP3 20p11.23 prothymosin, alpha pseudogene 3 (gene sequence 34) ZNF339 20pter-q11.23 zinc finger protein 339 RPL15P1 20p11.23 ribosomal protein L15 pseudogene 1 CSRP2BP 20p11.23 CSRP2 binding protein ZNF133 20p11.23-p11.22 zinc finger protein 133 (clone pHZ-13) C20orf12 20p11.23 chromosome 20 open reading frame 12 POLR3F 20p11.23 polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa RBBP9 20p11.2 retinoblastoma binding protein 9 RPS19P1 20p11.23 ribosomal protein S19 pseudogene 1 SEC23B 20pter-p12.3 Sec23 homolog B (S. cerevisiae) LOC388789 20 hypothetical gene supported by AF147354 HARS2 20p11.23 histidyl-tRNA synthetase 2 HSPC072 20p11.23 HSPC072 protein C20orf78 20p11.23 chromosome 20 open reading frame 78 C20orf79 20 chromosome 20 open reading frame 79
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1614
- splicing 1746 - 148 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Dstn
Homologene
FAMILY actin-binding proteins ADF family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microfilament
basic FUNCTION This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin).
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein actin
cell & other
REGULATION
ASSOCIATED DISORDERS
ANIMAL & CELL MODELS