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FLASH GENE

Symbol

DSCR3

contributors: npt - updated : 03-05-2002

HGNC name	Down syndrome critical region gene 3
HGNC id	3044

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	21q22.3      Physical location : 38.595.725 - 38.639.833
Synonym name	Down syndrome critical region protein A
Synonym symbol(s)	DCRA, DSCRA, DSR3, MGC117385

DNA

TYPE	functioning gene
STRUCTURE	44.00 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D21S336 ,TTC1 - DSCR3 - D21S337 - D21S55 - DSCR4 - D21S342 - D21S339 - qter
Authors	Nakamura (97)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed DSCR3 8 - 3252 33 297 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain         Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain, heart, lung, pancreas, liver, kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine H beta 58

Homologene

FAMILY	pep8/h58 family
	VPS26 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION

involved in embryogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS