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FLASH GENE
Symbol DRGX contributors: mct/ npt - updated : 22/10/2008
HGNC name dorsal root ganglia homeobox
HGNC id 21536
Location 10q11.23      Physical location : 50.574.161 - 50.599.907
Synonym name
  • paired related homeobox-like 1
  • paired-like homeodomain trancription factor DRG11
    • Synonym symbol(s) PRRXL1, DRG11
    DNA
    TYPE functioning gene
    STRUCTURE 25.75 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 807 - 268 - Saito (1995)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousgangliasensory gangliadorsal root  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in embryonic dorsal root ganglion (DRG) and dorsal horn neurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • paired homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function in the establishment or maintenance of connectivity between some of these neurons and their central nervous system targets
  • playing a role in early postnatal survival of normally generated small primary afferent neurons innervating various kinds of peripheral tissues
  • paired domain transcription factor that is necessary for the assembly of the nociceptive circuitry in the spinal cord dorsal horn
  • required for the establishment of the first neuronal sensory relay along development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS