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FLASH GENE
Symbol DRG1 contributors: - updated : 11-06-2004
HGNC name developmentally regulated GTP binding protein 1
HGNC id 3029
Location 22q12.2      Physical location : 31.795.538 - 31.830.171
Synonym name neural precursor cell expressed, developmentally down-regulated 3
Synonym symbol(s) NEDD3, DRG
DNA
TYPE functioning gene
STRUCTURE 34.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map see PIB5PA
Physical map
SLC35E4 22q12.2 solute carrier family 35, member E4 LOC391328 22 similar to tum- transplantation antigen P198 DUSP18 22q12.1 dual specificity phosphatase 18 OSBP2 22q12.2 oxysterol binding protein 2 FLJ35801 22q12.2 hypothetical protein FLJ35801 ZCWCC1 22q12.2 zinc finger, CW-type with coiled-coil domain 1 FLJ20618 22q12.2 hypothetical protein FLJ20618 LOC388893 22 LOC388893 SMTN 22q12.2 smoothelin SELM 22q12.2 selenoprotein SelM PIB5PA 22q12.2 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A PLA2G3 22q11.2-q13.2 phospholipase A2, group III FLJ38628 22q12.3 hypothetical protein FLJ38628 AGTRL2 22q12.2 angiotensin II receptor-like 2 LIMK2 22q12.2 LIM domain kinase 2 PPP1R14BP1 22q12 protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 1 MGC17330 22q12.2 HGFL gene ZNF278 22q12.2 zinc finger protein 278 MGC15705 22q12.3 hypothetical protein MGC15705 FLJ20464 22q12.3 hypothetical protein FLJ20464 DRG1 22q12.2 developmentally regulated GTP binding protein 1 EIF4ENIF1 22q11.2 eukaryotic translation initiation factor 4E nuclear import factor 1 KIAA0542 22q12.2 KIAA0542 gene product PISD 22q12.2 phosphatidylserine decarboxylase LOC388894 22 similar to Phosphatidylserine decarboxylase proenzyme MGC50372 22q12.3 hypothetical protein MGC50372 FLJ23059 22q12.3 hypothetical protein FLJ23059 KIAA0645 22q12.2-q12.3 hypothetical protein FLJ23059 HSN44A4A 22q12.1-q12.3 hypothetical protein HSN44A4A YWHAH 22q12.2 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide LOC391329 22 similar to ribosomal protein S17 SLC5A1 22q12.3 solute carrier family 5 (sodium/glucose cotransporter), member 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Nedd3
Homologene
FAMILY NDRG gene family
CATEGORY regulatory , signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION a negative involment in the metastatic process in prostate cancer
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
  • GTP binding
  • binding to SCL in clones from human fetal liver and thymus
    • cell & other
    REGULATION
    induced by various chemical agents and antineoplastic drugs such as tunicamycin, mercaptoethanol and homocysteine
    Other developmentally regulated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene metastasis suppressor gene for prostate cancer that may serve as an useful prognostic marker
    Marker
    Therapy target
    ANIMAL & CELL MODELS