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FLASH GENE
Symbol DRD2 contributors: mct/pgu - updated : 31-08-2016
HGNC name dopamine receptor D2
HGNC id 3023
Corresponding disease
MD dystonia, myoclonic
Location 11q23.2      Physical location : 113.280.317 - 113.346.001
Synonym name
  • seven transmembrane helix receptor
  • dopamine receptor D2 isoform
  • Synonym symbol(s) DRD2A, D2R, D2DR
    DNA
    TYPE functioning gene
    STRUCTURE 65.68 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D11S84 - TYR - D11S35 - MMP8 - MMP10 - MMP8 - MMP3 - MMP12 - MMP7 - D11S385 - MMP13 - D11S611 - D11S384 - D11S424 - D11S444 - NCAM1 - DRD2 - D11S386 - D11S351 - D11S144 - D11S29 - HMBS - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2713 50.5 443 - 2015 26308580
  • D2L
  • exhibited calcium-dependent desensitization similar to that exhibited by endogenous autoreceptors
  • expression of D2S as the exclusive autoreceptor was insufficient for cocaine-induced plasticity, implying a functional role for the co-expression of D2S and D2L autoreceptors
  • 7 - 2626 47.2 414 - 2015 26308580
  • D2S
  • expression of D2S as the exclusive autoreceptor was insufficient for cocaine-induced plasticity, implying a functional role for the co-expression of D2S and D2L autoreceptors
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Nervousbrainmidbrain    Homo sapiens
     brainbasal nucleistriatum   Homo sapiens
     nervespinal nervesciatic  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousdopaminergic neuron Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, retina, eye anterior segment, lens choroid, RPE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large intracytoplasmic loop between segments 5 and 6
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • adenylate cyclase inhibiting, involved in the regulation of appetite and growth hormone
  • having distinct functional roles with dopamine in the cortex versus the striatum
  • TAAR1 and DRD2 have functional and physical interactions that could be critical for the modulation of the dopaminergic system by TAAR1
  • dopamine DRD2 signaling suppresses human osteoclastogenesis
  • new function of DRD2 in dendritic spine morphogenesis
  • key receptor that mediates dopamine-associated brain functions such as mood, reward, and emotion
  • play likely an important role in the activity-dependent functional development of the retina
  • differential roles of DRD1 and DRD2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization
  • exhibits pleiotropic responses to the biogenic amine dopamine (DA) to mediate complex central nervous system functions through activation of G proteins and beta-arrestins
  • functional expression of DRD2 is regulated by tetraspanin 7-mediated postendocytic trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calnexin interactions critically regulate DRD2
  • NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA
  • functional interaction between TAAR1 and DRD2
  • expression of ZNF804A results in a statistically significant decrease in transcript levels of PDE4B and DRD2
  • association of ANKK1/DRD2 implicates the role of nicotine-related pathways and dopamine signaling in language processing, particularly in comprehension and phonological memory
  • CDK5-mediated phosphorylation of S321 inhibits DRD2 function, providing a novel regulatory mechanism for dopamine signaling
  • DRD2, via paraoxonase 2 and SESN2, keeps normal renal redox balance, which contributes to the maintenance of normal blood pressure
  • interactions between DRD2 and GNB5 are not mediated by endogenously expressed RGS7 proteins
  • is a prominent target for drug treatments in disorders where dopamine function is aberrant, such as schizophrenia
  • NCS1 interacts with both the G-protein-coupled receptor (GPCR) DRD2, regulating its internalization and surface expression, and the cognate kinases GRK1 and ADBRK1
  • TSPAN7 negatively affects DRD2-mediated signaling
  • cell & other
    REGULATION
    Other regulated by DNA methylation
  • ADRBK1 or ADRBK2 promotes its phosphorylation and regulates its post-endocytic trafficking
  • ASSOCIATED DISORDERS
    corresponding disease(s) MD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    dysfunction during adolescence impairs neuronal circuits and working memory, and indicate that adolescent interventions to prevent aberrant DRD2 activity protect against cognitive impairment
    constitutional       loss of function
    is a critical mechanism mediating cocaine-induced glutamate plasticity in ventral tegmental area (VTA) neurons
    Susceptibility
  • to opium addiction in Iranian population
  • to schizophrenia
  • to suicide
  • to speech disfluency
  • to nicotine dependence (ND) and alcohol dependence (AD)
  • Variant & Polymorphism SNP , other
  • may be association of the S311C variant with schizophrenia
  • 141C ins/del asociated with schizophrenia and alcoholism
  • allele A1-A1 increases the risk of opium addiction in Iranian population
  • polymorphisms that may be involved in the biological susceptibility to suicide
  • C allele at rs6277 is associated with increased susceptibility to speech disfluency
  • association of DRD2 and its adjacent gene ankyrin repeat and kinase domain containing 1 (ANKK1) with nicotine dependence (ND) and alcohol dependence (AD)
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    potential impact of future therapeutic strategies that enhance DRD2 signaling in the nucleus accumbens (NAc)
    tumor  
    DRD2 and SSTR3 seem to be the most promising targets for pharmacological treatment of pituitary adenomas
    ANIMAL & CELL MODELS