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FLASH GENE

Symbol

DRAM2

contributors: mct/npt - updated : 01-07-2015

HGNC name	DNA-damage regulated autophagy modulator 2
HGNC id	28769

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CORD21 retinal cone-rod dystrophy 21
Location	1p13.3      Physical location : 111.659.954 - 111.682.838
Synonym name	transmembrane protein 77
	damage regulated autophagy modulator 2
Synonym symbol(s)	PRO180, TMEM77, WWFQ154, MGC54289, RP5-1180E21.1

DNA

TYPE	functioning gene
STRUCTURE	22.89 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178454 9 - 1901 NP_848549 - 266 - 2015 25983245

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye retina       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining retinal pigment epithelium (RPE)     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six putative transmembrane domains

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Tmem77
	homolog to rattus Tmem77

intraspecies

homolog to DRAM1

Homologene

FAMILY

DRAM/TMEM150 family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	effector molecule that is critical for TP53-mediated apoptosis
	DRAM2 is a lysosomal protein, but again unlike DRAM1 its overexpression does not modulate autophagy
	DRAM2 expression contributes to autophagy induction
	transmembrane lysosomal protein thought to play a role in the initiation of autophagy
	is essential for photoreceptor survival
	might be involved in the process of photoreceptor renewal and recycling to preserve visual function

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CORD21

Susceptibility

Variant & Polymorphism

Candidate gene	reduced expression of DRAM2 may contribute to enhanced cell survival in tumor cells (Park 2009)
Marker
Therapy target

ANIMAL & CELL MODELS