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FLASH GENE
Symbol DRAM2 contributors: mct/npt - updated : 01-07-2015
HGNC name DNA-damage regulated autophagy modulator 2
HGNC id 28769
Corresponding disease
CORD21 retinal cone-rod dystrophy 21
Location 1p13.3      Physical location : 111.659.954 - 111.682.838
Synonym name
  • transmembrane protein 77
  • damage regulated autophagy modulator 2
  • Synonym symbol(s) PRO180, TMEM77, WWFQ154, MGC54289, RP5-1180E21.1
    DNA
    TYPE functioning gene
    STRUCTURE 22.89 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1901 - 266 - 2015 25983245
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six putative transmembrane domains
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Tmem77
    homolog to rattus Tmem77
    intraspecies homolog to DRAM1
    Homologene
    FAMILY
  • DRAM/TMEM150 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • effector molecule that is critical for TP53-mediated apoptosis
  • DRAM2 is a lysosomal protein, but again unlike DRAM1 its overexpression does not modulate autophagy
  • DRAM2 expression contributes to autophagy induction
  • transmembrane lysosomal protein thought to play a role in the initiation of autophagy
  • is essential for photoreceptor survival
  • might be involved in the process of photoreceptor renewal and recycling to preserve visual function
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CORD21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • reduced expression of DRAM2 may contribute to enhanced cell survival in tumor cells (Park 2009)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS