basic FUNCTION
| inhibitor of class II and III genes transcription |
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controls TBP binding and maintenance on DNA that is largely independent of a canonical TATA sequence |
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represses both basal and activated levels of transcription |
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physiologically involved in the control of cell proliferation |
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inhibiting the assembly of the preinitiation complex and controling the rate of RNA polymerase II transcription |
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specifically involved in neuroblastoma pathogenesis and may be considered a new neuroblastoma biomarker |
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TBP, BTAF1, and DR1 establish a regulatory circuit that controls downstream core promoter element-dependent versus TATA-dependent transcription b |
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BTAF1 and DR1 predominantly affect TBP dissociation rates, leaving the association rate unchanged |