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FLASH GENE
Symbol DR1 contributors: mct/npt/pgu - updated : 26-02-2009
HGNC name down-regulator of transcription 1, TBP-binding (negative cofactor 2)
HGNC id 3017
Location 1p22.1      Physical location : 93.811.477 - 93.828.146
Synonym name
  • down-regulator of transcription 1
  • TATA-binding protein-associated phosphoprotein 3
  • down-regulator of transcription 1, TBP-binding (negative
    cofactor 2)
  • negative cofactor 2-beta
  • Synonym symbol(s) TBPAP, NC2, NC2-BETA
    EC.number 2.7.1.112
    DNA
    TYPE functioning gene
    STRUCTURE 16.67 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    CDC7 1p22 CDC7 cell division cycle 7 (S. cerevisiae) LOC391056 1 similar to RIKEN cDNA 9430077D24 gene TRAP2 1p22 tumor rejection antigen (gp96) pseudogene 2 TGFBR3 1p33-p32 transforming growth factor, beta receptor III (betaglycan, 300kDa) BRDT 1p21-p22 bromodomain, testis-specific ABHD7 1p22.1 abhydrolase domain containing 7 LOC339526 1p22.1 similar to hypothetical protein FLJ20481 LOC126598 1p22.1 similar to template acyivating factor-I alpha LOC284697 1p22.1 similar to agCP5986 KIAA1107 1p22.1 KIAA1107 protein LOC388649 1 similar to 1700028K03 protein GLMN 1p22.1 glomulin, FKBP associated protein FLJ13150 1p22.1 hypothetical protein FLJ13150 GFI1 1p22 growth factor independent 1 EVI5 1p22 ecotropic viral integration site 5 RPL5 1p22.1-p21.3 ribosomal protein L5 LOC388650 1 similar to RIKEN cDNA 2900024C23 M96 1p22.1 likely ortholog of mouse metal response element binding transcription factor 2 CGI-100 1pter-q31.3 CGI-100 protein NY-SAR-41 1p22.1 sarcoma antigen NY-SAR-41 DR1 1p22.1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) FLJ20275 BCAR3 1p22.1 breast cancer anti-estrogen resistance 3 LOC388651 1 LOC388651 HSU15552 1p22.1 acidic 82 kDa protein mRNA GCLM 1p22.1 glutamate-cysteine ligase, modifier subunit ABCA4 1p22.1 ATP-binding cassette, sub-family A (ABC1), member 4 PARG1 1p22.1 PTPL1-associated RhoGAP 1 LOC391057 1 similar to uracil DNA glycosylase ABCD3 1p22.1-p21.3 ATP-binding cassette, sub-family D (ALD), member 3 F3 1p22.1-p21 coagulation factor III (thromboplastin, tissue factor) MGC45474 1p22.1 hypothetical protein MGC45474 CNN3 1p21 calponin 3, acidic MGC19780 1p22.1 hypothetical protein MGC19780
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3222 19.31 176 - 1992 1339312
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines Hela cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a histone fold motif at the N terminus
  • a TBP binding domain
  • a glutamine and alanine rich region
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • NC2 beta/DR1 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibitor of class II and III genes transcription
  • controls TBP binding and maintenance on DNA that is largely independent of a canonical TATA sequence
  • represses both basal and activated levels of transcription
  • physiologically involved in the control of cell proliferation
  • inhibiting the assembly of the preinitiation complex and controling the rate of RNA polymerase II transcription
  • specifically involved in neuroblastoma pathogenesis and may be considered a new neuroblastoma biomarker
  • TBP, BTAF1, and DR1 establish a regulatory circuit that controls downstream core promoter element-dependent versus TATA-dependent transcription b
  • BTAF1 and DR1 predominantly affect TBP dissociation rates, leaving the association rate unchanged
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer with DRAP1
  • forms a stable complex with TATA-binding protein (TBP) on promoters
  • INTERACTION
    DNA binding to TATA-box (TBP)
    RNA
    small molecule
    protein BTAF1 negatively regulates TBP and DR1 binding to active promoters
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS