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FLASH GENE
Symbol DPYSL4 contributors: mct/npt - updated : 08-06-2010
HGNC name dihydropyrimidinase-like 4
HGNC id 3016
Location 10q26.3      Physical location : 134.000.413 - 134.019.278
Synonym name
  • collapsin response mediator protein 3
  • UNC33-like phosphoprotein 4
  • ULIP4 protein
  • Synonym symbol(s) CRMP3, DRP-4, ULIP4
    EC.number 3.5.4.2
    DNA
    TYPE functioning gene
    STRUCTURE 18.87 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TCERG1L 10q26.3 transcription elongation regulator 1-like BNIP3 14q11.2-q12 BCL2/adenovirus E1B 19kDa interacting protein 3 C10orf39 10q26.3 chromosome 10 open reading frame 39 DPYSL4 10q26 dihydropyrimidinase-like 4 PKE 10q26.3 PKE protein kinase LOC387724 10 LOC387724 KIAA1674 10q26.3 KIAA1674 LOC170394 10q26.3 hypothetical protein BC011630 LOC170393 10q26.3 hypothetical protein LOC170393 LOC387725 10 hypothetical gene supported by AK097584 INPP5A 10q26.3 inositol polyphosphate-5-phosphatase, 40kDa NKX6-2 10q26 NK6 transcription factor related, locus 2 (Drosophila) DKFZp434A1721 10q26.3 hypothetical protein DKFZp434A1721 FLJ25954 10q26.3 hypothetical protein FLJ25954 LOC390011 10 LOC390011 GPR123 10q26 G protein-coupled receptor 123 KIAA1768 10q26.3 KIAA1768 protein C10orf23 UTF1 10q26 undifferentiated embryonic cell transcription factor 1 VENTX2 10q26.3 VENT-like homeobox 2 ADAM8 10q26.3 a disintegrin and metalloproteinase domain 8 TUBGCP2 10q26.3 tubulin, gamma complex associated protein 2 ZNF511 10q26.3 zinc finger protein 511
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2732 - 572 - Hamajima (1996)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed mostly in the nervous system during development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an amidohydrolase motif
  • HOMOLOGY
    interspecies ortholog to murine Dpysl4
    ortholog to rattus dpysl4
    Homologene
    FAMILY
  • dehydropyrimidinase family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text N-terminal truncated DPYSL4 underwent nuclear translocation through nuclear pores (Aylsworth 2009)
    basic FUNCTION
  • may be involved in the axonal growth during development by transducing signals from different semaphorins
  • having an important role in dendrite arborization, guide-posts navigation, and neuronal plasticity (Quach 2008)
  • key modulator of cytoskeletons during neurite outgrowth in response to chemorepulsive guidance molecules (Aylsworth 2009)
  • role in attenuating neurite outgrowth possibility through inhibiting microtubule polymerization, and also revealed its novel association with vimentin during nuclear condensation prior to neuronal death (Aylsworth 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • form a large complex composed of DPYSL5 and other unidentified proteins (Inatome 2000)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DPYSL5 (Inatome 2000)
  • CRHR2 activation decrease DPYSL4 expression in hippocampal neurons via a mechanism that is dependent on PLC/PKC signaling pathways
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Down syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS