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FLASH GENE
Symbol DPYSL3 contributors: mct - updated : 27-09-2018
HGNC name dihydropyrimidinase-like 3
HGNC id 3015
Location 5q32      Physical location : 146.770.370 - 146.833.260
Synonym name
  • collapsin response mediator protein 4 long
  • testicular secretory protein Li 7
  • unc-33-like phosphoprotein 1
  • Synonym symbol(s) DRP3, ULIP, CRMP4, DRP-3, CRMP-4, CRMP-4, LCRMP, ULIP-1
    EC.number 3.5.4.2
    DNA
    TYPE functioning gene
    STRUCTURE 119.25 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure a myoD/myogenin site downstream the promoter
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391837 5 similar to transient receptor potential cation channel, subfamily C, member 6; transient receptor potential channel 6 MGC21644 5q32 hypothetical protein MGC21644 FLJ23654 5q32 hypothetical protein FLJ23654 LOC153770 5q32 similar to protein related with psoriasis LARS 5q32 leucyl-tRNA synthetase KIAA1311 5q32 KIAA1311 protein POU4F3 5q31-q32 POU domain, class 4, transcription factor 3 TCERG1 5q31 transcription elongation regulator 1 (CA150) GPR151 5q32 G protein-coupled receptor 151 PPP2R2B 5q31-q33 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform MGC22688 5q32 hypothetical protein MGC22688 DPYSL3 5q32 dihydropyrimidinase-like 3 KIAA0555 5q32 dihydropyrimidinase-like 3 SPINK1 5q31 serine protease inhibitor, Kazal type 1 LOC391838 5 similar to low affinity N-formyl peptide receptor SCGB3A2 5q32 secretoglobin, family 3A, member 2 LOC389336 5 similar to AVLV472 LOC391839 5 similar to elongation factor 1 gamma SPINK5 5q32 serine protease inhibitor, Kazal type, 5 LOC340060 5q33.1 similar to alpha-5 collagen ECG2 5q33.1 similar to alpha-5 collagen FLJ13962 5q33.1 hypothetical protein FLJ13962 SP329 5q33.1 hypothetical protein SP329 HTR4 5q31-q33 5-hydroxytryptamine (serotonin) receptor 4 ADRB2 5q31.3 adrenergic, beta-2-, receptor, surface KIAA1985 LOC255187 5q33.1 hypothetical LOC255187
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5496 - 684 - 2016 2747532
  • CRMP4b
  • CRMP4a and CRMP4b exhibit opposing functions in neurite outgrowth
  • CRMP4b expression was higher in gastric cancer cell lines than in the normal gastric epithelial cell
  • CRMP4a and CRMP4b have opposite effects on cell proliferation, migration, and invasion in gastric cancer
  • 14 - 5066 - 570 - 2016 2747532
  • CRMP4a
  • CRMP4a and CRMP4b exhibit opposing functions in neurite outgrowth
  • CRMP4a and CRMP4b have opposite effects on cell proliferation, migration, and invasion in gastric cancer.
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain     Homo sapiensFetal
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    an amidohydrolase motif
    conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Dpysl3
    homolog to rattus dpysl3
    Homologene
    FAMILY
  • dehydropyrimidinase family
  • collapsin response mediator protein (CRMP) family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • dihydropyrimidase activity
  • may regulate vesicle function in the growth cone
  • DPYSL3 and GAP43 are both involved in neurite outgrowth, a crucial process for the differentiation of neurons
  • regulates the inflammatory response of activated microglia
  • dual role for DPYSL3 in regulating the actin and microtubule growth cone cytoskeleton
  • DPYSL2 and DPYSL3 interacted with one another coordinately to promote growth cone development and axonal elongation
  • DPYSL2 and DPYSL3 form likely complexes to bridge microtubules and actin and thus work cooperatively to regulate growth cone development and axonal elongation
  • CRMP1 and DPYSL3 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex
  • is a novel negative regulator of osteoblast differentiation
  • is a protein exhibiting sex-different expression during sexual differentiation of the hypothalamic sexually dimorphic nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a key physiological substrate of GSK3B in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubule
  • increased DPYSL3 expression mediated by the activation of VEGFA signaling facilitates gastric tumor growth and metastasis, which may have clinical implications associated with a reduced survival rate in gastric cancer patients
  • CAPN2 may contribute to the promoter methylation of DPYSL3 to repress its transcription, leading to the metastasis of Prostate carcinoma via enhancing VEGFC expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Down syndrome
    Susceptibility
  • to Autism spectrum disorders (ASD)
  • to amyotrophic lateral sclerosis (ALS)
  • Variant & Polymorphism SNP , other
  • variant (S541Y) of DPYSL3 in a male ASD patient, mutation resulting in altered DPYSL3 function in neurons, more severe in the male, indicating a functional link between a case-specific, rare variant of DPYSL3, and several characteristics of ASD, including sexual differences
  • association between the rs147541241 variant and ALS; this variant variant appears to shorten motor neuron survival through a detrimental effect on axonal growth
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Crmp4-deficient mice (Crmp4-/- ) displayed a 40p100 increase in bone mass, increased mineral apposition rate, and bone formation rate, compared to wild-type controls