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FLASH GENE
Symbol DPYS contributors: - updated : 07-05-2007
HGNC name dihydropyrimidinase
HGNC id 3013
Corresponding disease
DPYS dihydropyrimidinuria associated
Location 8q22      Physical location : 105.391.652 - 105.479.277
Synonym name hydantoinase
Synonym symbol(s) DHP, DHPase
EC.number 3.5.2.2
DNA
TYPE functioning gene
STRUCTURE 87.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Physical map
TFCP2L3 8q22.3 angiopoietin 1 NCALD 8q22-q23 neurocalcin delta LOC392257 8 similar to IAP-associated factor VIAF1; phosducin-like 2 RRM2B 8q23.1 ribonucleotide reductase M2 B (TP53 inducible) DD5 8q22 ribonucleotide reductase M2 B (TP53 inducible) ODF1 8q22.3 outer dense fiber of sperm tails 1 TIEG 8q22.2 TGFB inducible early growth response OAZIN 8q22.3 ornithine decarboxylase antizyme inhibitor LOC389679 8 similar to hypothetical protein ATP6V1C1 8q22.3 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1 LOC389680 8 similar to MGC39526 protein BAALC 8q22.3 brain and acute leukemia, cytoplasmic FZD6 8q22.3-q23.1 frizzled homolog 6 (Drosophila) CTHRC1 8q22.3 collagen triple helix repeat containing 1 MFTC 8q22.3 mitochondrial folate transporter/carrier DKFZP564O0463 8q22.3 DKFZP564O0463 protein TARBP2P 8q22-q24 TAR (HIV) RNA binding protein 2 pseudogene RIMS2 8q22.3 regulating synaptic membrane exocytosis 2 DCSTAMP 8q23 DC-specific transmembrane protein DPYS 8q22 dihydropyrimidinase ST7 7q31.1-q31.3 suppression of tumorigenicity 7 LOC392258 8 similar to ribosomal protein L29 LOC392259 8 similar to KIAA0779 protein ZFPM2 8q22.3-q23 zinc finger protein, multitype 2 LOC346887 8q23.1 similar to hypothetical protein FLJ30794 OXR1 8q23 oxidation resistance 1 STARS 8q23.1 striated muscle activator of Rho-dependent signaling ANGPT1 8q22.3-q23 angiopoietin 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 2500 56.6 519 - Hamajima
- - - 3800
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
amidohydrolase domain
HOMOLOGY
interspecies homolog to murine Dpys
homolog to C.elegans c47e12.8
Homologene
FAMILY desydropyrimidinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • conversion of 5.6-dihydronacil to 3-ureidopropionate
  • detoxifying 5-fluorouracil
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    pyrimidine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DPYS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS