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FLASH GENE
Symbol DPY19L2 contributors: mct/npt/pgu - updated : 12-07-2022
HGNC name dpy-19-like 2 (C. elegans)
HGNC id 19414
Corresponding disease
SPGF9 spermatogenic failure 9
Location 12q14.2      Physical location : 63.952.692 - 64.062.354
Synonym name
  • dpy-19-like protein 2
  • spermatogenesis associated 34
    • Synonym symbol(s) FLJ32949, FLJ36166, SPATA34, SPGF9
    DNA
    TYPE functioning gene
    STRUCTURE 109.66 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4064 87.2 758 - 2006 16526957
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 9 transmembrane domain protein
    • HOMOLOGY
    Homologene
    FAMILY
  • DPY19L family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,int
    text
  • DPY19L2 is at the inner nuclear membrane to maintain the developing acrosome
    • basic FUNCTION
  • is necessary in men for sperm head elongation and acrosome formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FAM209B is the first interacting partner of DPY19L2, and the second protein that is essential for acrosome biogenesis that localizes to the inner nuclear membrane
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    homozygous in globozoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS