Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DPT contributors: mct - updated : 02-11-2014
HGNC name dermatopontin
HGNC id 3011
Location 1q24.2      Physical location : 168.664.700 - 168.698.442
Synonym symbol(s) DMTP, DERM, TRAMP
DNA
TYPE functioning gene
STRUCTURE 33.75 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CD3Z 1q22-q23 CD3Z antigen, zeta polypeptide (TiT3 complex) SRD5BP1 1q23-q25 steroid-5-beta-reductase, beta polypeptide pseudogene 1 CREG 1q24 cellular repressor of E1A-stimulated genes MGC21854 1q22-q24 hypothetical protein MGC21854 MPZL1 1q23.2 myelin protein zero-like 1 FLJ21047 1q23.3 hypothetical protein FLJ21047 SAC DKFZP564B167 1q24 DKFZP564B167 protein PC326 1q23.3 PC326 protein GCSH 16q24 glycine cleavage system protein H (aminomethyl carrier) GPR161 1q23.3 G protein-coupled receptor 161 MGC3794 1q23.2 putative MAPK activating protein RPL34P1 1q23-q24 ribosomal protein L34 pseudogene 1 LOC375035 1q23.3 hypothetical protein LOC375035 MGC12538 1q23.3 hypothetical protein MGC12538 TBX19 1q23-q24 T-box 19 LOC391131 1 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 XCL2 1q23-q25 chemokine (C motif) ligand 2 XCL1 1q23 chemokine (C motif) ligand 1 DPT 1q12-q23 dermatopontin MGC4473 1q23.3 hypothetical protein MGC4473 LOC391132 1 similar to ribosomal protein L29 ATP1B1 1q23.2-q23.3 ATPase, Na+/K+ transporting, beta 1 polypeptide NME7 1q24 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) BLZF1 1q24-q25 basic leucine zipper nuclear factor 1 (JEM-1) LOC57821 1q24 hypothetical protein LOC57821 SLC19A2 1q23.2-q23.3 solute carrier family 19 (thiamine transporter), member 2 F5 1q23.2-q23.3 coagulation factor V (proaccelerin, labile factor) SELP 1q23.2-q41.2 selectin P (granule membrane protein 140kDa, antigen CD62) SELL 1q23.2-q23.3 selectin L (lymphocyte adhesion molecule 1) SELE 1q23.2-q23.1 selectin E (endothelial adhesion molecule 1) MGC9084 1q23.3 hypothetical protein MGC9084 FLJ10706 1q23.3 hypothetical protein FLJ10706 PACE-1 1q23.3 ezrin-binding partner PACE-1 KIFAP3 1q23.2 kinesin-associated protein 3 MRPS10P1 1q23.2 mitochondrial ribosomal protein S10 pseudogene 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1749 22 201 - 2011 21398523
EXPRESSION
Rna function mRNA was strongly expressed in human fetal and adult liver, kidney, and spleen
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver     Homo sapiens
Nervousgangliasensory gangliadorsal root  
 nervespinal nervesciatic  
Reproductivefemale systemuterus   
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a binding site in DPT for FN1 was identified as the DPT-4 (PHGQVVVAVRS) peptide
  • HOMOLOGY
    Homologene
    FAMILY dermatopontin family.
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text
  • located mainly in the cytoplasm of several cell types in the liver, and also in the extracellular matrix of the skin
  • basic FUNCTION
  • may be mediating adhesion by cell surface integrin binding
  • promoting cell adhesion and cytoplasmic spreading of dermal fibroblasts and accelerating the assembly of collagen into fibrils
  • may be one of the regulators used to remodel the uterine extracellular matrix for pregnancy
  • can play various roles in different tissues and might be a molecule related to carcinogenesis and the progression of hepatocellular carcinoma via possible interaction with TGF-beta1 and other potential mechanisms
  • promotes fibronectin fibril formation probably by changing the fibronectin conformation
  • has an accelerating role in fibroblast cell adhesion to the provisional matrix in the initial stage of wound healing
  • first non-integrin protein that can activate Fibronectin (FN) and induce FN fibril formation, and in a context of FN activation, may help a wound to heal by accumulating in the wound either from the surrounding ECM or from the serum
  • acidic extracellular matrix (ECM) protein that plays a critical role in both ECM structure and wound healing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • proteoglycan binding
  • binding to decorin
  • downstream target of vitamin D receptor
  • promotes strong epidermal cell adhesion via alpha3beta1 integrin and syndecan
  • interacted with Fibronectin (FN) and fibrin and enhanced the cell adhesion activity of FN
  • a binding site in DPT for FN1 was identified as the DPT-4 (PHGQVVVAVRS) peptide, and the major binding site in FN1 for DPT was the 14th type III repeat (III14) domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in uterine leiomyoma and keloids
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Dpt-kockout mice exhibit an Ehlers-Danlos syndrome phenotype