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FLASH GENE
Symbol DPPA2 contributors: mct - updated : 30-01-2013
HGNC name developmental pluripotency associated 2
HGNC id 19197
Location 3q13.13      Physical location : 109.012.635 - 109.035.364
Synonym name
  • pluripotent embryonic stem cell-related protein
  • cancer/testis antigen 100
  • embryonic stem cell (ESC) associated transcript 15-2
  • Embryo-cancer sequence A
  • Synonym symbol(s) PESCRG1, CT100, ECAT15-2, ECSA
    DNA
    TYPE functioning gene
    STRUCTURE 22.73 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1393 - 298 - 2012 21896782
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus     Homo sapiensAdult
    Reproductivefemale systemplacenta    Homo sapiensAdult
     male systemtestis    Homo sapiensAdult
    Urinarykidney     Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiensAdult
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • DPPA2 and DPPA4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line
  • regulates chromatin structures, playing important roles in the maintenance of pluripotency and proliferation of embryonic stem cells
  • involved not only in the normal development of lung but also in the pathogenesis of non-small cell lung cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the regulatory region of NKX2-5 in ESCs, suggesting that it has important roles in lung development, where it is no longer expressed, by leaving epigenetic marks from earlier developmental stages (PMID;
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    promising target for antigen-specific immunotherapy in in non-small cell lung cancer
    ANIMAL & CELL MODELS