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FLASH GENE
Symbol DPP9 contributors: mct - updated : 07-05-2019
HGNC name dipeptidylpeptidase 9
HGNC id 18648
Location 19p13.3      Physical location : 4.675.245 - 4.723.855
Synonym name dipeptidyl peptidase IV-related protein-2
Synonym symbol(s) DPRP2, FLJ16073, DP9, DPLP9, DPP IX, DPRP-2, DPRP2
EC.number 3.4.14.5
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 48.62 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 4273 - 892 two isoforms localize to separate subcellular compartments, DPP9-long localizes preferentially to the nucleus 2014 24562348
  • DPP9-long represents a significant fraction of total DPP9 in cells, under steady-state conditions
    • 13 - 2293 - 518 two isoforms localize to separate subcellular compartments 2014 24562348
  • DPP9-short is present in the cytosol
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
    Endocrinepancreas   highly
    Reproductivemale systemtestis    Homo sapiens
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificfibroblast Homo sapiens
    Reproductivespermatid Homo sapiens
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a serine protease motif, GWSYG, identical to that found in DPP IV
  • Arg-Gly-Asp integrin-binding motif not required for the impairment of cell survival, cell adhesion or wound healing
    • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY peptidase s9b family, DPPIV gene family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • having post-proline dipeptidyl aminopeptidase activity
  • influence cell-extracellular matrix interactions, and thus may regulate tissue remodeling
  • physiological role of DPP8, DPP9 in the male reproductive system
  • important role for DPP9 in peptide turnover and antigen presentation
  • novel role of DPP9 in regulating cell survival and proliferation through modulating molecular signaling cascades
  • biological roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis
  • DPP8 and DPP9 are involved in multiple cellular pathways including antigen maturation, cellular homeostasis, energy metabolism, and cell viability
  • involved in various cellular pathways including amino acid recycling, antigen maturation, cellular homeostasis, and viability
  • regulatory role of DPP9 in cell movement, and likely DPP9 is implicated in tissue and tumor growth and metastasis
  • importance of DPP8 and DPP9 on adipogenesis
  • DPP9 enzyme activity regulates metabolic pathways in neonatal liver and gut
  • accumulation of DPP9 on the edges of plasma membranes of fibroblasts and keratinocytes adhering to surface supports the idea of possible role of DPP9 in cell adhesion
  • potential role of DPP9 in peptide processing within endosomal/vesicular compartment
  • DPP8 and DPP9 are intracellular N-terminal dipeptidyl peptidases (preferentially postproline) associated with pathophysiological roles in immune response and cancer biology
  • intracellular prolyl peptidase implicated in immunoregulation
  • DPP9 has roles in antigen presentation and B cell signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DPP9 and DPP8, associate with HRAS, a key signal molecule of the EGF receptor signaling pathway, suggesting an important signaling role of DPP9 in the regulation of survival and proliferation pathways
  • UBA2 interacts with both SUMO1 and SUMO2, both DPP8 and DPP9 showed a strong preference toward SUMO1 binding
  • SUMO1, or more likely, a sumoylated protein, acts as an allosteric regulator of DPP9
  • DPP9 and SUMO1 interact in a SIM-independent manner, suggesting a novel surface on SUMO1 for noncovalent interactions with downstream effectors
  • noncovalent interaction of DPP9 with SUMO1 leads to activation of the peptidase
  • cytosolic serine dipeptidyl peptidases DPP8 and DPP9 suppress inflammasome activation upstream of NLRP1 and CARD8 in human keratinocytes and peripheral blood mononuclear cells
  • DPP9 binds directly to NLRP1 and CARD8, and this interaction may contribute to the inhibition of NLRP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    exhibited impaired cell adhesion, migration in transwells and monolayer wound healing on collagen I, fibronectin and Matrigel
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • inactivation of Dpp9 enzymatic activity does not lead to any perturbations in mouse hematopoiesis