Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DPP8 contributors: npt/mct - updated : 07-05-2019
HGNC name dipeptidyl-peptidase 8
HGNC id 16490
Location 15q22      Physical location : 65.737.998 - 65.810.035
Synonym name
  • dipeptidyl peptidase VIII
  • dipeptidyl peptidase IV-related protein-1
  • prolyl dipeptidase DPP8
  • Synonym symbol(s) DPRP1, MSTP097, MSTP135, MSTP141, MGC26191, FLJ20283, FLJ14920, DP8
    EC.number 3.4.14.5
    DNA
    TYPE functioning gene
    STRUCTURE 72.03 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4096 - 882 - Ajami (2008)
    18 - 3796 - 782 - Ajami (2008)
    21 - 4086 103 898 - Ajami (2008)
    20 - 4079 - 847 - Ajami (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
     salivary gland   highly
    Lymphoid/Immunelymph node   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminus having functional importance of the C-terminal loop to the whole family of prolyl dipeptidases
  • mono polymer monomer , dimer
    HOMOLOGY
    intraspecies homolog to DPP4
    homolog to FAP
    Homologene
    FAMILY
  • peptidase S9B family
  • DPPIV subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • capable of cleaving the peptide bond after a penultimate proline residue
  • T cell activation and immune function
  • involved in cleavage of the N-terminal two residues of
  • CXCL10, CXCL11 and CXCL12
  • influence cell-extracellular matrix interactions, and thus may regulate tissue remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component predominantly dimeric
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBA2 interacts with both SUMO1 and SUMO2, both DPP8 and DPP9 showed a strong preference toward SUMO1 binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    exhibited impaired cell migration on collagen I and impaired wound healing on collagen I and fibronectin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS