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FLASH GENE
Symbol DPP6 contributors: mct/npt - updated : 23-04-2009
HGNC name dipeptidylpeptidase 6
HGNC id 3010
Corresponding disease
MRD33 mental retardation, autosomal dominant 33
Location 7q36.2      Physical location : 153.584.418 - 154.685.994
Synonym name
  • CD26-related dipeptidyl aminopeptidase-like protein
  • dipeptidylpeptidase VI
  • dipeptidylpeptidase 6
  • Synonym symbol(s) DPPX, MGC46605
    EC.number 3.4.14.6
    DNA
    TYPE functioning gene
    STRUCTURE 936.22 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GALNT15 7q36.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15 GALNT11 7q34-q36 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) LOC392153 7 similar to TSH receptor suppressor element-binding protein-1; TSEP-1 LOC389600 7 LOC389600 MLL3 7q36 myeloid/lymphoid or mixed-lineage leukemia 3 LOC220832 7q36.2 similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) LOC155100 7q36.2 similar to T-complex protein 1 XRCC2 7q36.1 X-ray repair complementing defective repair in Chinese hamster cells 2 LOC392154 7 similar to ATP synthase B chain, mitochondrial precursor ARP3BETA 7q346 similar to ATP synthase B chain, mitochondrial precursor LOC392155 7 similar to SMT3 suppressor of mif two 3 homolog 2 LOC346547 7q36.2 similar to envelope protein LOC392156 7 similar to ppg3 DPP6 7q dipeptidylpeptidase 6 PAXIP1L 7q36.3 PAX transcription activation domain interacting protein 1 like HTR5A 7q36.1 5-hydroxytryptamine (serotonin) receptor 5A LOC389601 7 LOC389601 INSIG1 7q36 insulin induced gene 1 EN2 7q36.2 engrailed homolog 2 LOC392157 7 similar to RIKEN cDNA 9630008K15 gene MGC20460 7q36.3 hypothetical protein MGC20460 SHH 7q36 sonic hedgehog homolog (Drosophila) LOC389602 7 hypothetical gene supported by AK124321 LOC346305 7q36.3 similar to hypothetical protein Tb927.2.4050 LOC285890 7q36.3 hypothetical LOC285890 C7orf13 7q36 chromosome 7 open reading frame 13 RNF32 7q36 ring finger protein 32 C7orf2 7q36 chromosome 7 open reading frame 2 C7orf3 7q36 chromosome 7 open reading frame 3 HLXB9 7q36 homeo box HB9 LOC392158 7 similar to S-adenosylmethionine decarboxylase KIAA0010 7q36.3 ubiquitin-protein isopeptide ligase (E3) DNAJB6 7q36.3 DnaJ (Hsp40) homolog, subfamily B, member 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 4542 97.5 865 prominently expressed in brain regions where Kv4 subunits are also expressed Yokotani, Jerng, Strop (2004), Nadal (2006)
    - - 4460 - 803 prominently expressed in brain regions where Kv4 subunits are also expressed Yokotani, Jerng, Strop (2004), Nadal (2006)
    5 - 4571 - 801 prominently expressed in brain regions where Kv4 subunits are also expressed Jerng, Strop (2004), Nadal (2006)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an additional serine near the "active" site
  • mono polymer dimer
    HOMOLOGY
    intraspecies homolog to dipeptidylpeptidase
    homolog to the related protein DPP-IV
    Homologene
    FAMILY
  • peptidase family S9B
  • dipeptidyl aminopeptidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in the physiological processes of brain function
  • essential component of the native cardiac I(to) channel complex in heart (Radicke 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of the transient outward current in the heart (Alders 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD33
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Idiopathic Ventricular Fibrillation (see VFI1) (Alders 2009)
    Susceptibility to amyotrophic lateral sclerosis
    Variant & Polymorphism SNP strongly associated with susceptibility to amyotrophic lateral sclerosis (Dupre 20098)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS