Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DPP10 contributors: mlc - updated : 24-11-2007
HGNC name dipeptidylpeptidase 10
HGNC id 20823
Location 2q14.1      Physical location : 115.199.898 - 116.602.324
Synonym name
  • dipeptidyl peptidase like protein 2
  • dipeptidyl peptidase IV-related protein 3
    • Synonym symbol(s) DPRP3, KIAA1492, DPL2, DPPY
    DNA
    TYPE functioning gene
    STRUCTURE 682.00 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4464 - 789 highly in the brain Ren, Chen (2006)
  • contains a distinct 5' UTR and has an alternative exon at the 5' end of the coding region
  • has a shorter and distinct N-terminus when compared to the long isoform
  • lacking dipeptidyl peptidase activity
    • 26 - 4863 90.9 796 - Ren, Chen (2006)
    the longer transcript and encodes the 'long' isoform
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala  
    nervousbrainbasal nuclei   
    Nervousbraindiencephalonthalamus  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Dpp10
    ortholog to ratus Dpp10_predicted
    intraspecies homolog to DPP6
    Homologene
    FAMILY
  • peptidase family S9B
  • dipeptidyl peptidase IV (DPIV) gene family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • cleaving terminal dipeptides from cytokines and chemokines, and presents a potential new target for asthma therapy
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds KCND2, KCND1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    asthma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS