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FLASH GENE
Symbol DPM2 contributors: mct - updated : 25-02-2016
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
HGNC id 3006
Corresponding disease
CDG1U congenital disorder of glycosylation, type Iu
Location 9q34.11      Physical location : 130.697.373 - 130.700.763
Synonym name
  • dolichol phosphate-mannose synthase 2
  • dolichol phosphate-mannose biosynthesis regulatory protein
    • Synonym symbol(s) MGC21559, MGC111193, FLJ80013
    EC.number 2.4.1.83
    DNA
    TYPE functioning gene
    STRUCTURE 3.39 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1561 92 84 - 2005 16280320
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • two transmembrane domains
  • a C terminal ER localisation
    • HOMOLOGY
    Homologene
    FAMILY
  • DPM2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • regulating the biodynthesis of dolichol-phosphate mannose by DPM1 stabilyzing DPM3 which stabilizes DPM1
  • regulating glycosyl phosphatidylinositol biosynthesis (first step)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DPM1
  • DPM3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1U
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS