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FLASH GENE
Symbol DPH3 contributors: mct/npt - updated : 18-10-2005
HGNC name DPH3, KTI11 homolog (S. cerevisiae)
HGNC id 27717
Location 3p25.1      Physical location : 16.298.568 - 16.306.496
Synonym name
  • DelGEF interacting protein 1
  • CSL-type zinc finger-containing protein 2
  • deafness locus putative guanine nucleotide exchange factor
  • interacting protein 1
  • diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1
  • DPH3 homolog
  • Synonym symbol(s) DESR1, DELGIP1, MGC20197, KTI11, DELGIP, DPH3A, ZCSL2
    DNA
    TYPE functioning gene
    STRUCTURE 7.93 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 4065 9 82 ubiquitously expressed -
    being a functional protein
    2 splicing 3990 6 57 ubiquitously expressed -
  • being a nonfunctional protein
  • lacking exon 2
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vessel   predominantly
    Nervousbrain   moderately
    Reproductivemale systemtestis  moderately
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DPH-type zinc finger
  • HOMOLOGY
    interspecies ortholog to murine Zcsl2
    Homologene
    FAMILY
  • DPH3 family
  • zinc finger protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • being essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphteria toxin and by pseudomonas exotoxin A
  • playing a possible role in the secretion process indicated by the increase of extracellular release of proteoglycans produced by the DPH3 down-regulation
  • stimulating binding of SERGEF to SEC5
  • acting in diphthamide biosynthesis (Webb 2008)
  • in addition to having a role in diphthamide biosynthesis, is also involved in modulating the functions of the Elongator complex in yeast (Liu 2006)
  • having a physiological importance in development (Liu 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text negative regulation of protein secretion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • SERGEF
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS