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FLASH GENE
Symbol DPH1 contributors: npt/ - updated : 23-05-2006
HGNC name DPH1 homolog (S. cerevisiae)
HGNC id 3003
Location 17p13.3      Physical location : 1.933.430 - 1.946.724
Synonym name
  • ovarian cancer gene 1
  • diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae)
  • candidate tumor suppressor in ovarian cancer 1
  • DPH-like 1 (S. cerevisiae)
  • diphthamide biosynthesis protein 2 homolog-like 1
    • Synonym symbol(s) OVCA1, DPH2L, DPH2L1
    DNA
    TYPE functioning gene
    STRUCTURE 13.29 kb     13 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2200 - 443 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreast   
     female systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Dph1
    Homologene
    FAMILY
  • DPH1/DPH2 family
  • DPH1 subfamily
    • CATEGORY immunity/defense , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • required for diphteria toxin resistance
  • acting in diphthamide biosynthesis (Webb 2008)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative regulator of proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RBM8A, RBM8B
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the majority of ovarian tumors and breast tumors
    tumoral   deletion    
    frequently deleted in ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS